@article{fdi:010088837,
  title = {{S}tabilization of infant formulas against lipid oxidation : what are the key structural levers ?},
  author = {{C}ancalon, {M}. and {B}arouh, {N}. and {H}emery, {Y}ouna and {B}area, {B}. and {D}urand, {E}. and {B}ourlieu-{L}acanal, {C}. and {V}illeneuve, {P}.},
  editor = {},
  language = {{ENG}},
  abstract = {{I}nfant follow-on formulas ({IFF}) mimic human milk. {T}his study aimed to identify the key structural levers that influence oxidative stability of {IFF}. {R}epresentative model {IFF} of marketed products in term of lipid composition were formulated with varying droplet size, lipid droplet core composition, and interfacial composition using different emulsifiers (soy lecithin or dairy phospholipids [{DPL}]). {T}he oxidative stability of model {IFF} was assessed in accelerated storage conditions. {N}o significant stabilization effect based on the lipid droplet core composition was observed. {H}owever, the nature of the interface, influenced by the emulsifier type, had an impact. {M}odel {IFF} with {DPL} showed no loss of tocopherols and peroxide value was up to twice lower than those with soy lecithin after 20 days. {T}his effect was particularly pronounced for the 0.4 mu m droplets. {T}hese results suggest that model {IFF} with {DPL} had a greater oxidative stability, likely due to the presence of sphingomyelin and the formation of a rigidified domain at the droplet surface. {M}odel {IFF} with 0.4 mu m droplets stabilized with soy lecithin, especially when added to the water phase, showed a tocopherols loss twice as high as that of {IFF} with {DPL}. {T}hese results indicate that oxidative stability of {IFF} is more influenced by the chemical environment rather than droplet size.{P}ractical {A}pplication: {I}nfant follow-on formulas ({IFF}) aim to ensure an adequate nutritional intake to support the proper development and infant growth. {T}herefore, {IFF} must be stable against degradation phenomena such as lipid oxidation and have a composition and structure that are as biomimetic as possible to mature breast milk. {T}his study provides key information for the development of {IFF} with a lipid composition and structure that are suitable for the infant nutritional needs and have an acceptable resistance to lipid oxidation. {M}ore generally, these results can be applied to all dispersed systems in the form of oil-in-water emulsions with a similar composition. {H}omogenization pressure had an impact on the initial vitamin {A} content. {H}owever, the investigation of the influence of droplet size during the storage has shown a limited effect on oxidative stability, which depended more on the chemical environment. {A}lthough the presence of colloidal structures promoted the diffusion of prooxidant compounds and sped up lipid oxidation, dairy phospholipids as emulsifiers, on the contrary, slowed down lipid oxidation. {B}iomimetic infant follow-on formulas having large droplet size (0.7 mu m) and based on dairy lipids show improved oxidative stability. image},
  keywords = {antioxidant ; emulsifier ; infant formula ; lipid oxidation ; lipid structure},
  booktitle = {},
  journal = {{E}uropean {J}ournal of {L}ipid {S}cience and {T}echnology},
  volume = {{E}arly access},
  numero = {},
  pages = {[14 ]},
  ISSN = {1438-7697},
  year = {2023},
  DOI = {10.1002/ejlt.202300161},
  URL = {https://www.documentation.ird.fr/hor/fdi:010088837},
}