@article{fdi:010088818,
  title = {{OROSOMUCOID} {PROTEIN} 1 regulation of sphingolipid synthesis is required for nodulation in {A}eschynomene evenia},
  author = {{N}ouwen, {N}ico and {P}ervent, {M}. and {E}l {M}'{C}hirgui, {F}. and {T}ellier, {F}. and {R}ios, {M}aelle and {A}raujo, {N}. {H}. and {K}lopp, {C}. and {G}ressent, {F}. and {A}rrighi, {J}ean-{F}ran{\c{c}}ois},
  editor = {},
  language = {{ENG}},
  abstract = {{L}egumes establish symbiotic interactions with nitrogen-fixing rhizobia that are accommodated in root-derived organs known as nodules. {R}hizobial recognition triggers a plant symbiotic signaling pathway that activates 2 coordinated processes: infection and nodule organogenesis. {H}ow these processes are orchestrated in legume species utilizing intercellular infection and lateral root base nodulation remains elusive. {H}ere, we show that {A}eschynomene evenia {OROSOMUCOID} {PROTEIN} 1 ({A}e{ORM}1), a key regulator of sphingolipid biosynthesis, is required for nodule formation. {U}sing {A}. evenia orm1 mutants, we demonstrate that alterations in {A}e{ORM}1 function trigger numerous early aborted nodules, defense-like reactions, and shorter lateral roots. {A}ccordingly, {A}e{ORM}1 is expressed during lateral root initiation and elongation, including at lateral root bases where nodule primordium form in the presence of symbiotic bradyrhizobia. {S}phingolipidomics revealed that mutations in {A}e{ORM}1 lead to sphingolipid overaccumulation in roots relative to the wild type, particularly for very long-chain fatty acid-containing ceramides. {T}aken together, our findings reveal that {A}e{ORM}1-regulated sphingolipid homeostasis is essential for rhizobial infection and nodule organogenesis, as well as for lateral root development in {A}. evenia.},
  keywords = {},
  booktitle = {},
  journal = {{P}lant {P}hysiology},
  volume = {194},
  numero = {3},
  pages = {1611--1630},
  ISSN = {0032-0889},
  year = {2024},
  DOI = {10.1093/plphys/kiad642},
  URL = {https://www.documentation.ird.fr/hor/fdi:010088818},
}