@article{fdi:010088804,
  title = {{E}ffect of isoenergetic substitution of cheese with other dairy products on blood lipid markers in the fasted and postprandial state : an updated and extended systematic review and meta-analysis of randomized controlled trials in adults},
  author = {{P}radeilles, {R}ebecca and {N}orris, {T}. and {S}ellem, {L}. and {M}arkey, {O}.},
  editor = {},
  language = {{ENG}},
  abstract = {{C}onsumption of fat as part of a cheese matrix may differentially affect blood lipid responses when compared with other dairy foods. {T}his systematic review was conducted to compare the impact of consuming equal amounts of fat from cheese and other dairy products on blood lipid markers in the fasted and postprandial state. {S}earches of {P}ub{M}ed ({M}edline), {C}ochrane {C}entral and {E}mbase databases were conducted up to mid-{J}une 2022. {E}ligible human randomized controlled trials ({RCT}s) investigated the effect of isoenergetic substitution of hard or semi-hard cheese with other dairy products on blood lipid markers. {R}isk of bias ({R}o{B}) was assessed using the {C}ochrane {R}o{B} 2.0 tool. {R}andom-effects meta-analyses assessed the effect of >= 2 similar dietary replacements on the same blood lipid marker. {O}f 1491 identified citations, 10 articles were included ({R}o{B}: all some concerns). {P}ooled analyses of 7 {RCT}s showed a reduction in fasting total cholesterol, {LDL}-{C} and {HDL}-{C} concentrations after >= 14 d mean daily intake of 135 g cheese (weighted mean difference [{WMD}]: -0.24 mmol/{L}; 95% confidence interval ({CI}): -0.34, -0.15; {I}-2 = 59.8%, {WMD}: -0.19 mmol/{L}; 95% {CI}: -0.27, -0.12; {I}-2 = 42.8%, and {WMD}: -0.04 mmol/{L}; 95% {CI}: -0.08, -0.00; {I}-2 = 58.6%, respectively) relative to similar to 52 g/d butter. {W}e found no evidence of a benefit from replacing cheese for >= 14 d with milk on fasting blood lipid markers (n = 2). {L}imited postprandial {RCT}s, described in narrative syntheses, suggested that cheese-rich meals may induce differential fed-state lipid responses compared with some other dairy matrix structures, but not butter (n <= 2). {I}n conclusion, these findings indicate that dairy fat consumed in the form of cheese has a differential effect on blood lipid responses relative to some other dairy food structures. {H}owever, owing to considerable heterogeneity and limited studies, further confirmation from {RCT}s is warranted.},
  keywords = {adults ; butter ; cardiovascular disease prevention ; cheese ; dairy ; structure ; fasting lipid profile ; dairy matrix ; lipids ; lipoproteins ; saturated fat ; whole dairy},
  booktitle = {},
  journal = {{A}dvances in {N}utrition},
  volume = {14},
  numero = {6},
  pages = {1579--1595},
  ISSN = {2161-8313},
  year = {2023},
  DOI = {10.1016/j.advnut.2023.09.003},
  URL = {https://www.documentation.ird.fr/hor/fdi:010088804},
}