@article{fdi:010088685,
  title = {{B}othrops atrox and {B}othrops lanceolatus venoms in vitro investigation : composition, procoagulant effects, co-factor dependency, and correction using antivenoms},
  author = {{L}arr{\'e}ch{\'e}, {S}. and {B}ousquet, {A}. and {C}hevillard, {L}. and {G}ahoual, {R}. and {J}ourdi, {G}. and {D}upart, {A}. {L}. and {B}achelot-{L}oza, {C}. and {G}aussem, {P}. and {S}iguret, {V}. and {C}hippaux, {J}ean-{P}hilippe and {M}{\'e}garbane, {B}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}othrops venoms are rich in enzymes acting on platelets and coagulation. {T}his action is dependent on two major co-factors, i.e., calcium and phospholipids, while antivenoms variably neutralize venom-related coagulopathy effects. {O}ur aims were (i) to describe the composition of {B}. atrox and {B}. lanceolatus venoms; (ii) to study their activity on the whole blood using rotational thromboelastometry ({ROTEM}); (iii) to evaluate the contribution of calcium and phospholipids in their activity; and (iv) to compare the effectiveness of four antivenoms ({B}othrofav ({TM}), {I}noserp ({TM}) {S}outh {A}merica, {A}ntivipmyn ({TM}) {TRI}, and {P}oli{V}al-{ICP} ({TM})) on the procoagulant activity of these two venoms. {V}enom composition was comparable. {B}oth venoms exhibited hypercoagulant effects. {B}. lanceolatus venom was completely dependent on calcium but less dependent on phospholipids than {B}. atrox venom to induce in vitro coagulation. {T}he four antivenoms neutralized the procoagulant activity of the two venoms; however, with quantitative differences. {B}othrofav ({TM}) was more effective against both venoms than the three other antivenoms. {T}he relatively similar venom-induced effects in vitro were unexpected considering the opposite clinical manifestations resulting from envenomation (i.e., systemic bleeding with {B}. atrox and thrombosis with {B}. lanceolatus). {I}n vivo studies are warranted to better understand the pathophysiology of systemic bleeding and thrombosis associated with {B}othrops bites.},
  keywords = {{B}othrops ; coagulation ; venom composition ; {ROTEM} ; co-factor ; antivenom ; {GUYANE} {FRANCAISE} ; {PEROU} ; {BRESIL} ; {MARTINIQUE} ; {AMERIQUE} {LATINE} ; {AMERIQUE} {CENTRALE}},
  booktitle = {},
  journal = {{T}oxins},
  volume = {15},
  numero = {10},
  pages = {614 [21 p.]},
  year = {2023},
  DOI = {10.3390/toxins15100614},
  URL = {https://www.documentation.ird.fr/hor/fdi:010088685},
}