@article{fdi:010088678,
  title = {{P}revalence of {HIV} drug resistance among adolescents receiving {ART} in {C}ameroon with low- or high-level viraemia},
  author = {{D}jiyou, {A}. {B}. {D}. and {P}enda, {C}. and {M}adec, {Y}. and {N}gondi, {G}. {D}. and {M}oukoko, {A}. and {E}boumbou, {C}. {E}. and {A}ghokeng {F}obang, {A}velin},
  editor = {},
  language = {{ENG}},
  abstract = {{O}bjectives {T}o characterize {HIV} drug resistance ({HIVDR}) below and above the {WHO} threshold of 1000 copies/m{L}, considered for the definition of {HIV} {ART} failure in resource-limited settings. {M}ethods {F}rom a cohort of 280 adolescents (aged 10-19 years) receiving {ART} for at least 6 months, genotypic resistance testing ({GRT}) was attempted for two groups of participants: participants with low-level viraemia [{LLV}; viral load ({VL}) 200-999 copies/m{L}] and those in virological failure ({VF}; confirmed {VL} >= 1000 copies/m{L}) using an in-house method. {T}he {S}tanford {HIV}alg {P}rogram was used to identify relevant {HIVDR} mutations and predict the efficacy of the newly introduced tenofovir-lamivudine-dolutegravir combination.{R}esults {GRT} was successfully performed in 54/58 (93.1%) eligible participants, of which 28/31 (90.3%) were in {VF} and 26/27 (96.3%) had {LLV}. {A} high level of resistance was found both in adolescents with {LLV} and those in {VF}, with respectively 84.6% (22/26) and 75.0% (21/28) of participants harbouring at least one {HIVDR} mutation. {NRTI}s and {NNRTI}s were the most affected drug classes in both population groups. {I}n contrast, {PI}s were not significantly affected and dolutegravir was expected to be active for all participants tested. {H}owever, for the newly introduced dolutegravir-based combination, functional monotherapy (dolutegravir only) was potentially possible for 22.7% (5/22) of the participants with {LLV}.{C}onclusions {O}ur findings show that the 1000 copies/m{L} threshold is not an indicator of virological success and we call for a revision of the current {WHO} definition of {VF} in resource-limited countries.},
  keywords = {{CAMEROUN}},
  booktitle = {},
  journal = {{J}ournal of {A}ntimicrobial {C}hemotherapy},
  volume = {78},
  numero = {},
  pages = {2938--2942},
  ISSN = {0305-7453},
  year = {2023},
  DOI = {10.1093/jac/dkad334},
  URL = {https://www.documentation.ird.fr/hor/fdi:010088678},
}