@article{fdi:010088673,
  title = {{D}urability of the deltamethrin-treated polypropylene long-lasting net {L}ife{N}et® in a pyrethroid resistance area in south western {B}enin : a phase {III} trial},
  author = {{D}j{\`e}nontin, {A}. and {A}lfa, {D}. and {B}ouraima, {A}. and {S}oares, {C}. and {D}ahounto, {A}. and {C}orn{\'e}lie, {S}ylvie and {E}grot, {M}arc and {D}amien, {G}. and {R}emou{\'e}, {F}ranck and {S}agna, {A}. {B}. and {M}oiroux, {N}icolas and {P}ennetier, {C}{\'e}dric},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground {L}ong-lasting insecticidal bed nets ({LLIN}s) are a key measure for preventing malaria and their evaluation is coordinated by the {W}orld {H}ealth {O}rganization {P}esticide {E}valuation {S}cheme ({WHOPES}). {L}ife{N}et(({R})) was granted {WHOPES} time-limited interim recommendation in 2011 after successful {P}hase {I} and {P}hase {II} evaluations. {H}ere, we evaluated the durability and community acceptance of {L}ife{N}et(({R})) in a {P}hase {III} trial from {J}une 2014 to {J}une 2017 in {B}enin rural area. {M}ethods {A} prospective longitudinal, cluster-randomized, controlled trial with households as the unit of observation was designed to assess the performance of {L}ife{N}et ({R}) over a three-year period, using a {WHOPES} fully recommended {LLIN} ({P}erma{N}et(({R})) 2.0) as a positive control. {T}he primary outcomes were the bioassay performance using {WHO} cone assays and tunnel tests, the insecticide content and physical integrity. {R}esults {A}t baseline, 100% of {LLIN}s were within the tolerance limits of their target deltamethrin concentrations. {B}y 36 months only 17.3% of {L}ife{N}et(({R})) and 8.5% of {P}erma{N}et(({R})) {LLIN}s still were within their target deltamethrin concentrations. {D}espite these low rates, 100% of both {LLIN}s meet {WHO} efficacy criteria (>= 80% mortality or >= 95% knockdown or tunnel test criteria of >= 80% mortality or >= 90% blood-feeding inhibition) after 36 months using {WHO} cone bio-assays and tunnel tests. {T}he proportion of {LLIN}s in good physical condition was 33% for {L}ife{N}et(({R})) and 29% for {P}erma{N}et(({R})) after 36 months. {A}fter 36 {M} the survivorship was 21% and 26% for {L}ife{N}et ({R}) and {P}erma{N}et ({R}) respectively. {A}lthough both {LLIN}s were well accepted by the population, complaints of side effects were significantly higher among {L}ife{N}et(({R})) users than {P}erma{N}et(({R})) ones. {C}onclusion {L}ife{N}et(({R})) {LLIN}s did meet {WHO} criteria for bio-efficacy throughout the study period and were well accepted by the population. {T}his is an important step towards getting a full {WHO} recommendation for use in malaria endemic countries.},
  keywords = {{BENIN}},
  booktitle = {},
  journal = {{PL}o{S} {O}ne},
  volume = {18},
  numero = {9},
  pages = {e0291755 [16 p.]},
  ISSN = {1932-6203},
  year = {2023},
  DOI = {10.1371/journal.pone.0291755},
  URL = {https://www.documentation.ird.fr/hor/fdi:010088673},
}