@article{fdi:010088480,
  title = {{E}xtrachromosomal circular {DNA} and structural variants highlight genome instability in {A}rabidopsis epigenetic mutants},
  author = {{Z}hang, {P}. and {M}bodj, {A}ssane and {S}oundiramourtty, {A}. and {L}lauro, {C}. and {G}hesqui{\`e}re, {A}lain and {I}ngouff, {M}. and {S}lotkin, {R}.{K}. and {P}ontvianne, {F}. and {C}atoni, {M}. and {M}irouze, {M}arie},
  editor = {},
  language = {{ENG}},
  abstract = {{A}bundant extrachromosomal circular {DNA} (ecc{DNA}) is associated with transposable element ({TE}) activity. {H}owever, how the ecc{DNA} compartment is controlled by epigenetic regulations and what is its impact on the genome is understudied. {H}ere, using long reads, we sequence both the ecc{DNA} compartment and the genome of {A}rabidopsis thaliana mutant plants affected in {DNA} methylation and post-transcriptional gene silencing. {W}e detect a high load of {TE}-derived ecc{DNA} with truncated and chimeric forms. {O}n the genomic side, on top of truncated and full length {TE} neo-insertions, we detect complex structural variations ({SV}s) notably at a disease resistance cluster being a natural hotspot of {SV}. {F}inally, we serendipitously identify large tandem duplications in hypomethylated plants, suggesting that {SV}s could have been overlooked in epigenetic mutants. {W}e propose that a high ecc{DNA} load may alter {DNA} repair pathways leading to genome instability and the accumulation of {SV}s, at least in plants.},
  keywords = {},
  booktitle = {},
  journal = {{N}ature {C}ommunications},
  volume = {14},
  numero = {},
  pages = {5236 [11 ]},
  ISSN = {2041-1723},
  year = {2023},
  DOI = {10.1038/s41467-023-41023-0},
  URL = {https://www.documentation.ird.fr/hor/fdi:010088480},
}