@article{fdi:010088365,
  title = {{A} chimeric vaccine protects farmed saltwater crocodiles from {W}est {N}ile virus-induced skin lesions},
  author = {{H}abarugira, {G}. and {H}arrison, {J}.{J}. and {M}oran, {J}. and {S}uen, {W}.{W}. and {C}olmant, {A}gathe and {H}obson-{P}eters, {J}. and {I}sberg, {S}.{R}. and {B}ielefeldt-{O}hmann, {H}. and {H}all, {R}.{A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{W}est {N}ile virus ({WNV}) causes skin lesions in farmed crocodiles leading to the depreciation of the value of their hides and significant economic losses. {H}owever, there is no commercially available vaccine designed for use in crocodilians against {WNV}. {W}e tested chimeric virus vaccines composed of the non-structural genes of the insect-specific flavivirus {B}injari virus ({B}in{JV}) and genes encoding the structural proteins of {WNV}. {T}he {B}in{JV}/{WNV} chimera, is antigenically similar to wild-type {WNV} but replication-defective in vertebrates. {I}ntramuscular injection of two doses of {B}in{JV}/{WNV} in hatchling saltwater crocodiles ({C}rocodylus porosus) elicited a robust neutralising antibody response and conferred protection against viremia and skin lesions after challenge with {WNV}. {I}n contrast, mock-vaccinated crocodiles became viraemic and 22.2% exhibited {WNV}-induced lesions. {T}his suggests that the {B}in{JV}/{WNV} chimera is a safe and efficacious vaccine for preventing {WNV}-induced skin lesions in farmed crocodilians.},
  keywords = {{AUSTRALIE}},
  booktitle = {},
  journal = {{NPJ} {V}accines},
  volume = {8},
  numero = {},
  pages = {93 [9 ]},
  ISSN = {2059-0105},
  year = {2023},
  DOI = {10.1038/s41541-023-00688-w},
  URL = {https://www.documentation.ird.fr/hor/fdi:010088365},
}