@article{fdi:010088338,
  title = {{E}ffect of drug pressure on promoting the emergence of antimalarial-resistant parasites among pregnant women in {G}hana},
  author = {{T}ornyigah, {B}. and {C}opp{\'e}e, {R}. and {H}ouze, {P}. and {K}usi, {K}. {A}. and {A}du, {B}. and {Q}uakyi, {I}. and {C}oleman, {N}. and {M}ama, {A}. and {D}eloron, {P}hilippe and {A}nang, {A}braham {K}. and {C}lain, {J}. and {T}ahar, {R}achida and {O}fori, {M}. {F}. and {T}uikue {N}dam, {N}icaise},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he continuous spread of antimalarial drug resistance is a threat to current chemotherapy efficacy. {T}herefore, characterizing the genetic diversity of drug resistance markers is needed to follow treatment effectiveness and further update control strategies. {H}ere, we genotyped {P}lasmodium falciparum resistance gene markers associated with sulfadoxine-pyrimethamine ({SP}) and artemisinin-based combination therapy ({ACT}) in isolates from pregnant women in {G}hana. {T}he prevalence of the septuple {IRN} {I}- {A}/{FG} {K} {GS}/{T}pfdhfr/pfdhps haplotypes, including the pfdhps {A}581{G} and {A}613{S}/{T} mutations, was high at delivery among post-{SP} treatment isolates (18.2%) compared to those of first antenatal care (before initiation of intermittent preventive treatment of malaria in pregnancy with sulfadoxine-pyrimethamine [{IPT}p-{SP}]; 6.1%; {P}?=?0.03). {R}egarding the pfk13 marker gene, two nonsynonymous mutations ({N}458{D} and {A}481{C}) were detected at positions previously related to artemisinin resistance in isolates from {S}outheast {A}sia. {T}hese mutations were predicted in silico to alter the stability of the pfk13 propeller-encoding domain. {O}verall, these findings highlight the need for intensified monitoring and surveillance of additional mutations associated with increased {SP} resistance as well as emergence of resistance against artemisinin derivatives.},
  keywords = {{GHANA}},
  booktitle = {},
  journal = {{A}ntimicrobial {A}gents and {C}hemotherapy},
  volume = {64},
  numero = {6},
  pages = {e02029--19 [9 ]},
  ISSN = {1098-6596},
  year = {2020},
  DOI = {10.1128/{AAC}.02029-19},
  URL = {https://www.documentation.ird.fr/hor/fdi:010088338},
}