Crossay E. auteur aut IRD Jullian Valérie auteur aut IRD Trinel M. auteur aut IRD Sagnat D. auteur aut IRD Hamel D. auteur aut IRD Groppi E. auteur aut IRD Rolland C. auteur aut IRD Stigliani J. L. auteur aut IRD Mejia K. auteur aut IRD Cabanillas B. J. auteur aut IRD Alric L. auteur aut IRD Buscail E. auteur aut IRD El Kalamouni C. auteur aut IRD Mavingui P. auteur aut IRD Deraison C. auteur aut IRD Racaud-Sultan C. auteur aut IRD Fabre N. auteur aut IRD text journalArticle eng text/pdf born digital access Hura crepitans L. (Euphorbiaceae) is a thorn-covered tree widespread in South America, Africa and Asia which produces an irritating milky latex containing numerous secondary metabolites, notably daphnane-type diter-penes known as Protein Kinase C activators. Fractionation of a dichloromethane extract of the latex led to the isolation of five new daphnane diterpenes (1-5), along with two known analogs (6-7) including huratoxin. Huratoxin (6) and 4 & PRIME;,5 & PRIME;-epoxyhuratoxin (4) were found to exhibit significant and selective cell growth inhibition against colorectal cancer cell line Caco-2 and primary colorectal cancer cells cultured as colonoids. The un-derlying mechanism of 4 and 6 was further investigated revealing the involvement of PKC & zeta;in the cytostatic activity. specialized Euphorbiaceae Hura crepitans Daphnane diterpenes Colorectal cancer Caco-2 cells Protein Kinase C 076 020 050 90 117366 [17 ] 2023 0968-0896 https://www.documentation.ird.fr/hor/fdi:010088184 10.1016/j.bmc.2023.117366 0968-0896 [F B010088184] https://www.documentation.ird.fr/hor/fdi:010088184 https://www.documentation.ird.fr/intranet/publi/2023-08/010088184.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2023-08-25 2025-02-24 fdi:010088184 fre