@article{fdi:010088174,
  title = {{E}ffectiveness of intermittent preventive treatment with sulfadoxine-pyrimethamine in pregnancy : low coverage and high prevalence of {P}lasmodium falciparum dhfr-dhps quintuple mutants as major challenges in {D}ouala, an urban setting in {C}ameroon},
  author = {{M}oukoko, {C}. {E}. {E}. and {F}oko, {L}. {P}. {K}. and {A}yina, {A}. and {T}ornyigah, {B}. and {E}pote, {A}. {R}. and {P}enda, {I}. {C}. and {E}boumbou, {P}. {E}. and {E}bong, {S}. {B}. and {T}exier, {G}. and {N}sango, {S}. {E}. and {A}yong, {L}. and {T}uikue {N}dam, {N}icaise and {E}kobo, {A}. {S}.},
  editor = {},
  language = {{ENG}},
  abstract = {{I}ntermittent preventive treatment in pregnancy with sulfadoxine and pyrimethamine ({IPT}p-{SP}) is a key component in the malaria control strategy implemented in {A}frica. {T}he aim of this study was to determine {IPT}p-{SP} adherence and coverage, and the impact on maternal infection and birth outcomes in the context of widespread {SP} resistance in the city of {D}ouala, {C}ameroon. {C}linical and demographic information were documented among 888 pregnant women attending 3 health facilities, from the antenatal care visit to delivery. {P}ositive samples were genotyped for {P}. falciparum gene (dhfr, dhps, and k13) mutations. {T}he overall {IPT}p-{SP} coverage (& {GE};three doses) was 17.5%, and 5.1% received no dose. {P}. falciparum prevalence was 16%, with a predominance of submicroscopic infections (89.3%). {M}alaria infection was significantly associated with locality and history of malaria, and it was reduced among women using indoor residual spraying. {O}ptimal doses of {IPT}p-{SP} were significantly associated with reduced infection among newborns and women (secundiparous and multiparous), but there was no impact of {IPT}p-{SP} on the newborn bodyweight. {P}fdhfr-{P}fdhps quintuple mutants were over-represented ({IRNI}-{FGKAA}, {IRNI}-{AGKAA}), and sextuple mutants ({IRNI}-{AGKAS}, {IRNI}-{FGEAA}, {IRNI}-{AGKGS}) were also reported. {T}he {P}fk13 gene mutations associated with artemisinin resistance were not detected. {T}his study highlights the role of {ANC} in achieving optimal {SP} coverage in pregnant women, the mitigated impact of {IPT}p-{SP} on malaria outcomes, and the high prevalence of multiple {SP}-resistant {P}. falciparum parasites in the city of {D}ouala that could compromise the efficacy of {IPT}p-{SP}.},
  keywords = {malaria infection ; {IPT}p-{SP} ; pregnant women ; effectiveness ; dhfr ; dhps ; k13 mutations ; {C}ameroon ; {CAMEROUN} ; {DOUALA}},
  booktitle = {},
  journal = {{P}athogens},
  volume = {12},
  numero = {6},
  pages = {844 [20 p.]},
  year = {2023},
  DOI = {10.3390/pathogens12060844},
  URL = {https://www.documentation.ird.fr/hor/fdi:010088174},
}