@article{fdi:010088171,
  title = {6-{C}hloro-3-nitro-8-(phenylthio)-2-[(phenylthio)methyl] imidazo[1,2-a]pyridine},
  author = {{P}aoli-{L}ombardo, {R}. and {P}rimas, {N}. and {H}utter, {S}. and {B}ourgeade-{D}elmas, {S}andra and {B}oudot, {C}. and {C}astera-{D}ucros, {C}. and {J}acquet, {I}. and {C}ourtioux, {B}. and {A}zas, {N}. and {R}athelot, {P}. and {V}anelle, {P}.},
  editor = {},
  language = {{ENG}},
  abstract = {{A}s part of our ongoing antikinetoplastid structure-activity relationship study focused on positions 2 and 8 of the 3-nitroimidazo[1,2-a]pyridine scaffold, we were able to introduce a phenylthioether moiety at both position 2 and position 8 in one step. {U}sing a previously reported synthetic route developed in our laboratory, we obtained 6-chloro-3-nitro-8-(phenylthio)-2-[(phenylthio)methyl]imidazo[1,2-a]pyridine in 74% yield. {T}he in vitro cell viability of this compound was assessed on the {H}ep{G}2 cell line, and its in vitro activity was evaluated against the promastigote form of {L}. donovani, the axenic amastigote form of {L}. infantum and the trypomastigote blood stream form of {T}. b. brucei. {I}t showed low solubility in {H}ep{G}2 culture medium ({CC}50 > 7.8 & mu;{M}), associated with weak activity against both the promastigote form of {L}. donovani ({EC}50 = 8.8 & mu;{M}), the axenic amastigote form of {L}. infantum ({EC}50 = 9.7 & mu;{M}) and the trypomastigote blood stream form of {T}. b. brucei ({EC}50 = 12.8 & mu;{M}).},
  keywords = {imidazo [1, 2-a] pyridine ; nitroaromatic ; structure-activity ; relationship ; {L}eishmania spp ; {T}rypanosoma brucei},
  booktitle = {},
  journal = {{M}olbank},
  volume = {2023},
  numero = {2},
  pages = {{M}1613 [6 p.]},
  year = {2023},
  DOI = {10.3390/m1613},
  URL = {https://www.documentation.ird.fr/hor/fdi:010088171},
}