%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Laroche, L.
%A Ayhan, N.
%A Charrel, R.
%A Banuls, Anne-Laure
%A Prudhomme, J.
%T Persistence of Toscana virus in sugar and blood meals of phlebotomine sand flies : epidemiological and experimental consequences
%D 2023
%L fdi:010088089
%G ENG
%J Scientific Reports - Nature
%@ 2045-2322
%K ZONE MEDITERRANEENNE
%M ISI:000983866100016
%N 1
%P [7 ]
%R 10.1038/s41598-023-32431-9
%U https://www.documentation.ird.fr/hor/fdi:010088089
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/2023-07/010088089.pdf
%V 13
%W Horizon (IRD)
%X Many virological studies have tested the persistence of enveloped RNA viruses in various environmental and laboratory conditions and shown their short-term persistence. In this article, we analyzed Toscana virus (TOSV) infectivity, a pathogenic sandfly-borne phlebovirus, in two different conditions: in the sugar meal and blood meal of sand flies. Our results showed that TOSV RNA was detectable up to 15 days in sugar solution at 26 degrees C and up to 6 h in blood at 37 degrees C. Moreover, TOSV remains infective for 7 days in sugar solution and for minimum 6 h in rabbit blood. TOSV has shown persistent infectivity/viability under different conditions, which may have important epidemiological consequences. These results strengthen new hypotheses about the TOSV natural cycle, such as the possibility of horizontal transmission between sand flies through infected sugar meal.
%$ 052