@article{fdi:010088082,
  title = {{V}ector competence of sterile male {G}lossina fuscipes fuscipes for {T}rypanosoma brucei brucei : implications for the implementation of the sterile insect technique in a sleeping sickness focus in {C}had},
  author = {{M}ahamat, {M}. {H}. and {S}egard, {A}deline and {R}ayaisse, {J}. {B}. and {A}rgiles-{H}errero, {R}. and {P}arker, {A}. {G}. and {S}olano, {P}hilippe and {A}bd-{A}lla, {A}. {M}. {M}. and {B}ouyer, {J}. and {R}avel, {S}ophie},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground {H}uman {A}frican trypanosomiasis ({HAT}) is a neglected tropical disease caused by {T}rypanosoma brucei gambiense transmitted by tsetse flies in sub-{S}aharan {W}est {A}frica. {I}n southern {C}had the most active and persistent focus is the {M}andoul focus, with 98% of the reported human cases, and where {A}frican animal trypanosomosis ({AAT}) is also present. {R}ecently, a control project to eliminate tsetse flies ({G}lossina fuscipes fuscipes) in this focus using the sterile insect technique ({SIT}) was initiated. {H}owever, the release of large numbers of sterile males of {G}. f. fuscipes might result in a potential temporary increase in transmission of trypanosomes since male tsetse flies are also able to transmit the parasite. {T}he objective of this work was therefore to experimentally assess the vector competence of sterile males treated with isometamidium for {T}rypanosoma brucei brucei. {M}ethods {A}n experimental infection was set up in the laboratory, mimicking field conditions: the same tsetse species that is present in {M}andoul was used. {A} {T}. b. brucei strain close to {T}. b. gambiense was used, and the ability of the sterile male tsetse flies fed on blood with and without a trypanocide to acquire and transmit trypanosomes was measured. {R}esults {O}nly 2% of the experimentally infected flies developed an immature infection (midgut) while none of the flies developed a metacyclic infection of {T}. b. brucei in the salivary glands. {W}e did not observe any effect of the trypanocide used (isometamidium chloride at 100 mg/l) on the development of infection in the flies. {C}onclusions {O}ur results indicate that sterile males of the tested strain of {G}. f. fuscipes were unable to cyclically transmit {T}. b. brucei and might even be refractory to the infection. {T}he data of the research indicate that the risk of cyclical transmission of {T}. brucei by sterile male {G}. f. fuscipes of the strain colonized at {IAEA} for almost 40 years appears to be small.},
  keywords = {{T}setse ; {I}sometamidium ; {T}rypanocide ; {T}rypanosoma brucei gambiense ; {TCHAD}},
  booktitle = {},
  journal = {{P}arasites and {V}ectors},
  volume = {16},
  numero = {1},
  pages = {111 [6 ]},
  ISSN = {1756-3305},
  year = {2023},
  DOI = {10.1186/s13071-023-05721-4},
  URL = {https://www.documentation.ird.fr/hor/fdi:010088082},
}