@article{fdi:010087601,
  title = {{R}egulators of male and female sexual development are critical for the transmission of a malaria parasite},
  author = {{R}ussell, {A}. {J}. {C}. and {S}anderson, {T}. and {B}ushell, {E}. and {T}alman, {A}rthur and {A}nar, {B}. and {G}irling, {G}. and {H}unziker, {M}. and {K}ent, {R}. {S}. and {M}artin, {J}. {S}. and {M}etcalf, {T}. and {M}ontandon, {R}. and {P}andey, {V}. and {P}ardo, {M}. and {R}oberts, {A}. {B}. and {S}ayers, {C}. and {S}chwach, {F}. and {C}houdhary, {J}. {S}. and {R}ayner, {J}. {C}. and {V}oet, {T}. and {M}odrzynska, {K}. {K}. and {W}aters, {A}. {P}. and {L}awniczak, {M}. {K}. {N}. and {B}illker, {O}.},
  editor = {},
  language = {{ENG}},
  abstract = {{M}alaria transmission to mosquitoes requires a developmental switch in asexually dividing blood-stage par-asites to sexual reproduction. {I}n {P}lasmodium berghei, the transcription factor {AP}2-{G} is required and suffi-cient for this switch, but how a particular sex is determined in a haploid parasite remains unknown. {U}sing a global screen of barcoded mutants, we here identify genes essential for the formation of either male or fe-male sexual forms and validate their importance for transmission. {H}igh-resolution single-cell transcriptomics of ten mutant parasites portrays the developmental bifurcation and reveals a regulatory cascade of putative gene functions in the determination and subsequent differentiation of each sex. {A} male-determining gene with a {LOTUS}/{OST}-{HTH} domain as well as the protein interactors of a female-determining zinc-finger protein indicate that germ-granule-like ribonucleoprotein complexes complement transcriptional processes in the regulation of both male and female development of a malaria parasite.},
  keywords = {},
  booktitle = {},
  journal = {{C}ell {H}ost and {M}icrobe},
  volume = {31},
  numero = {2},
  pages = {305--319.e1--e10},
  ISSN = {1931-3128},
  year = {2023},
  DOI = {10.1016/j.chom.2022.12.011},
  URL = {https://www.documentation.ird.fr/hor/fdi:010087601},
}