@article{fdi:010087597,
  title = {{HERV}-{K} ({HML}-2) insertion polymorphisms in the 8q24.13 region and their potential etiological associations with acute myeloid leukemia},
  author = {{C}amargo-{F}orero, {N}. and {O}rozco-{A}rias, {S}. and {A}gudelo, {J}. {M}. {P}. and {G}uyot, {R}omain},
  editor = {},
  language = {{ENG}},
  abstract = {{H}uman endogenous retroviruses ({HERV}s) are {LTR} retrotransposons that are present in the human genome. {A}mong them, members of the {HERV}-{K} ({HML}-2) group are suspected to play a role in the development of different types of cancer, including lung, ovarian, and prostate cancer, as well as leukemia. {A}cute myeloid leukemia ({AML}) is an important disease that causes 1% of cancer deaths in the {U}nited {S}tates and has a survival rate of 28.7%. {H}ere, we describe a method for assessing the statistical association between {HERV}-{K} ({HML}-2) transposable element insertion polymorphisms (or {TIP}s) and {AML}, using whole-genome sequencing and read mapping using {TIP}_finder software. {O}ur results suggest that 101 polymorphisms involving {HERV}-{K} ({HML}-2) elements were correlated with {AML}, with a percentage between 44.4 to 56.6%, most of which (70) were located in the region from 8q24.13 to 8q24.21. {M}oreover, it was found that the {TRIB}1, {LRATD}2, {POU}5{F}1{B}, {MYC}, {PCAT}1, {PVT}1, and {CCDC}26 genes could be displaced or fragmented by {TIP}s. {F}urthermore, a general method was devised to facilitate analysis of the correlation between transposable element insertions and specific diseases. {F}inally, although the relationship between {HERV}-{K} ({HML}-2) {TIP}s and {AML} remains unclear, the data reported in this study indicate a statistical correlation, as supported by the {X}2 test with p-values < 0.05.},
  keywords = {},
  booktitle = {},
  journal = {{A}rchives of {V}irology},
  volume = {168},
  numero = {4},
  pages = {125 [12 p.]},
  ISSN = {0304-8608},
  year = {2023},
  DOI = {10.1007/s00705-023-05747-0},
  URL = {https://www.documentation.ird.fr/hor/fdi:010087597},
}