@article{fdi:010087514,
  title = {{L}iver cancer antiproliferative activity of a new nor-cucurbitacin from {M}areya micrantha {M}üll. {A}rg.},
  author = {{T}oussaint-{D}ouhor{\'e}, {G}. {Y}. and {S}oro, {Y}. and {O}u{\'e}draogo, {N}. and {V}aca-{G}arcia, {C}. and {K}offi-{A}ttioua, {B}. and {C}arraz, {M}a{\¨e}lle},
  editor = {},
  language = {{ENG}},
  abstract = {{M}areya micrantha {M}ull. {A}rg. ({E}uphorbiaceae) is a plant used in the {I}vorian traditional medicinal system for various medical properties such as laxative, oxytocic, intestinal infectious diseases, malaria, etc. {S}ix cucurbitacin derivatives (tetracyclic triterpenoids) are isolated from the leaves, stem barks or root barks of {M}. micrantha. {A}mong these compounds, 29-nor-2 beta,15 alpha,20 beta-trihydroxy-16 alpha-acetyl-3,1,22-trioxo-cucurbita-4,23-diene (1) is a new nor-cucurbitacin isolated from the leaves; 29-nor-1,2,3,4,5,10-dehydro-3,15 alpha,20 beta-trihydroxy-16 alpha-acetyl-11,22-dioxo-cucurbita-23-ene 2-{O}-beta-{D}-glucopyranoside (2) and 29-nor-2 beta,15 alpha,20 beta-trihydroxy-16 alpha-acetyl-3,11,22 trioxo-cucurbita-4,23-diene 2-{O}-beta-{D} glucopyranoside (3) are new nor-cucurbitacins recently discovered by us in leaves and isolated again for this study while dihydro-epi-isocucurbitacin {D} (4), tetrahydro-cucurbitacin {I} (5) and cucurbitacin {L} (6) are known cucurbitacins but newly isolated from the stem barks and the root barks of {M}. micrantha. {T}heir chemical structures are established according to spectral data ({UV}, {IR}, {MS} and 1{H}, 13{C} {NMR}). {T}heir antiproliferative activity is explored in vitro on the chemo-resistant human hepatocarcinoma cell line {H}ep3{B}. {C}ompound 1 showed a strong and selective antiproliferative activity against this cancer cell line ({IC}50 value of 0.12 +/- 0.05 mu {M}) when compared to normal hepatocytes {H}epa{RG}.},
  keywords = {{M}areya micrantha ; {N}or-cucurbitacin ; {A}ntiproliferative activity ; {H}epatocarcinoma cell line},
  booktitle = {},
  journal = {{F}itoterapia},
  volume = {166},
  numero = {},
  pages = {105471 [8 p.]},
  ISSN = {0367-326{X}},
  year = {2023},
  DOI = {10.1016/j.fitote.2023.105471},
  URL = {https://www.documentation.ird.fr/hor/fdi:010087514},
}