@article{fdi:010087452,
  title = {{S}taphylococcus aureus host spectrum correlates with methicillin resistance in a multi-species ecosystem},
  author = {{N}goubangoye, {B}. and {F}ouchet, {D}. and {B}oundenga, {L}. {A}. and {C}assan, {C}{\'e}cile and {A}rnathau, {C}. and {M}eugnier, {H}. and {T}soumbou, {T}. {A}. and {D}ibakou, {S}. {E}. and {E}kore, {D}. {O}. and {N}guema, {Y}. {O}. and {M}oukodoum, {N}. {D}. and {M}abicka, {A}. and {F}erry, {T}. and {R}asigade, {J}. {P}. and {P}rugnolle, {F}. and {B}anuls, {A}nne-{L}aure and {R}enaud, {F}. and {P}ontier, {D}.},
  editor = {},
  language = {{ENG}},
  abstract = {{A}lthough antibiotic resistance is a major issue for both human and animal health, very few studies have investigated the role of the bacterial host spectrum in its dissemination within natural ecosystems. {H}ere, we assessed the prevalence of methicillin resistance among {S}taphylococcus aureus ({MRSA}) isolates from humans, non-human primates ({NHP}s), micromammals and bats in a primatology center located in southeast {G}abon, and evaluated the plausibility of four main predictions regarding the acquisition of antibiotic resistance in this ecosystem. {MRSA} strain prevalence was much higher in exposed species (i.e., humans and {NHP}s which receive antibiotic treatment) than in unexposed species (micromammals and bats), and in {NHP} species living in enclosures than those in captivity-supporting the assumption that antibiotic pressure is a risk factor in the acquisition of {MRSA} that is reinforced by the irregularity of drug treatment. {I}n the two unexposed groups of species, resistance prevalence was high in the generalist strains that infect humans or {NHP}s, supporting the hypothesis that {MRSA} strains diffuse to wild species through interspecific transmission of a generalist strain. {S}trikingly, the generalist strains that were not found in humans showed a higher proportion of {MRSA} strains than specialist strains, suggesting that generalist strains present a greater potential for the acquisition of antibiotic resistance than specialist strains. {T}he host spectrum is thus a major component of the issue of antibiotic resistance in ecosystems where humans apply strong antibiotic pressure.},
  keywords = {natural ecosystem ; humans ; non-human primates ; bats ; micromammals ; strain biodiversity ; generalist and specialist strains ; antibiotic resistance ; {GABON}},
  booktitle = {},
  journal = {{M}icroorganisms},
  volume = {11},
  numero = {2},
  pages = {393 [19 p.]},
  year = {2023},
  DOI = {10.3390/microorganisms11020393},
  URL = {https://www.documentation.ird.fr/hor/fdi:010087452},
}