@article{fdi:010087438,
  title = {{H}igh plasma levels of neopterin are associated with increased mortality among children with severe malaria in {B}enin},
  author = {{B}lankson, {S}. {O}. and {R}ietmeyer, {L}. and {T}ettey, {P}. and {D}ikroh, {L}. and {T}ornyigah, {B}. and {A}damou, {R}. and {M}oussiliou, {A}. and {P}adounou, {C}. and {A}moussou, {A}. and {M}ensah, {B}. {A}. and {A}lao, {M}. {J}. and {A}wandare, {G}. and {T}uikue {N}dam, {N}icaise and {R}oussilhon, {C}. and {T}ahar, {R}achida},
  editor = {},
  language = {{ENG}},
  abstract = {{A}mong the barriers to accessing adequate treatment and high-level monitoring for malaria febrile patients is the lack of effective prognostic markers. {N}eopterin, which is a marker of monocyte/macrophage activation, was found have increased during severe malaria. {I}n this study, we used quantitative {ELISA} in order to assess the levels of plasma soluble neopterin in 151 patients from a cohort of {B}eninese children with severe malaria. {W}e evaluated the prognostic accuracy of this molecule in order to predict the outcome of the disease. {O}ur results show that neopterin levels were not significantly different between patients with different forms of severe malaria, including severe non-cerebral malaria ({SNCM}) and cerebral malaria ({CM}). {H}owever, the levels of this molecule were found to be higher in patients with severe malarial anemia ({SMA}) among both {CM} and {SNCM} cases (p-value = 0.02). {A}dditionally, the levels of this molecule were found to be higher in patients who died from these pathologies compared to those who survived among the two clinical groups (p-value < 0.0001) and within the same group (p-value < 0.0001 for the {CM} group, p-value = 0.0046 for the {SNCM} group). {T}he {AUC}-{ROC} for fatality among all the severe cases was 0.77 with a 95%{CI} of (0.69-0.85). {T}hese results suggest that plasma neopterin levels constitute a potential biomarker for predicting fatality among severe falciparum malaria patients.},
  keywords = {neopterin ; severe malaria ; cerebral malaria ; anemia ; {P}lasmodium falciparum ; {B}enin ; {BENIN}},
  booktitle = {},
  journal = {{D}iagnostics},
  volume = {13},
  numero = {3},
  pages = {528 [12 p.]},
  year = {2023},
  DOI = {10.3390/diagnostics13030528},
  URL = {https://www.documentation.ird.fr/hor/fdi:010087438},
}