%0 Journal Article %9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES %A Mensah, B. A. %A Ndong, I. C. %A Quashie, P. K. %A Guichet, E. %A Abuaku, B. %A Effah-Baafi, Y. %A Tapela, K. %A Asiedu, K. %A Appiedu-Addo, S. N. A. %A Obbeng, L. B. %A Amponsah, J. A. %A Kusi, K. A. %A Ofori, M. %A Ayouba, Ahidjo %A Courtin, David %A Tahar, Rachida %A Delaporte, E. %A Awandare, G. %A Tuikue Ndam, Nicaise %T Population-based sero-epidemiological investigation of the dynamics of SARS-CoV-2 infections in the Greater Accra Region of Ghana %D 2022 %L fdi:010087419 %G ENG %J Scientific Reports - Nature %@ 2045-2322 %K GHANA ; ACCRA %M ISI:000972599000040 %N 1 %P 21582 [9 ] %R 10.1038/s41598-022-25598-0 %U https://www.documentation.ird.fr/hor/fdi:010087419 %> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/2023-04/010087419.pdf %V 12 %W Horizon (IRD) %X The coronavirus disease 2019 (COVID-19) pandemic devastated countries worldwide, and resulted in a global shutdown. Not all infections are symptomatic and hence the extent of SARS-CoV-2 infection in the community is unknown. The paper presents the dynamics of the SARS-CoV-2 epidemic in the Greater Accra Metropolis, describing the evolution of seroprevalence through time and by age group. Three repeated independent population-based surveys at 6-week intervals were conducted in from November 2020 to July 2021. The global and by age-groups weighted seroprevalences were estimated and the risk factors for SARS-CoV-2 antibody seropositivity were assessed using logistic regression. The overall age-standardized SARS-CoV-2 antibody seroprevalence for both spike and nucleocapsid increased from 13.8% (95% CI 11.9, 16.1) in November 2020 to 39.6% (95% CI 34.8, 44.6) in July 2021. After controlling for gender, marital status, education level, and occupation, the older age group over 40 years had a higher odds of seropositivity than the younger age group (OR 3.0 [95% CI 1.1-8.5]) in the final survey. Pupils or students had 3.3-fold increased odds of seropositivity (OR 3.2 [95% CI 1.1-8.5]) compared to the unemployed. This study reinforces that, SARS-CoV-2 infections have been significantly higher than reported. %$ 052 ; 050