%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Mensah, B. A.
%A Ndong, I. C.
%A Quashie, P. K.
%A Guichet, E.
%A Abuaku, B.
%A Effah-Baafi, Y.
%A Tapela, K.
%A Asiedu, K.
%A Appiedu-Addo, S. N. A.
%A Obbeng, L. B.
%A Amponsah, J. A.
%A Kusi, K. A.
%A Ofori, M.
%A Ayouba, Ahidjo
%A Courtin, David
%A Tahar, Rachida
%A Delaporte, E.
%A Awandare, G.
%A Tuikue Ndam, Nicaise
%T Population-based sero-epidemiological investigation of the dynamics of SARS-CoV-2 infections in the Greater Accra Region of Ghana
%D 2022
%L fdi:010087419
%G ENG
%J Scientific Reports - Nature
%@ 2045-2322
%K GHANA ; ACCRA
%M ISI:000972599000040
%N 1
%P 21582 [9 ]
%R 10.1038/s41598-022-25598-0
%U https://www.documentation.ird.fr/hor/fdi:010087419
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/2023-04/010087419.pdf
%V 12
%W Horizon (IRD)
%X The coronavirus disease 2019 (COVID-19) pandemic devastated countries worldwide, and resulted in a global shutdown. Not all infections are symptomatic and hence the extent of SARS-CoV-2 infection in the community is unknown. The paper presents the dynamics of the SARS-CoV-2 epidemic in the Greater Accra Metropolis, describing the evolution of seroprevalence through time and by age group. Three repeated independent population-based surveys at 6-week intervals were conducted in from November 2020 to July 2021. The global and by age-groups weighted seroprevalences were estimated and the risk factors for SARS-CoV-2 antibody seropositivity were assessed using logistic regression. The overall age-standardized SARS-CoV-2 antibody seroprevalence for both spike and nucleocapsid increased from 13.8% (95% CI 11.9, 16.1) in November 2020 to 39.6% (95% CI 34.8, 44.6) in July 2021. After controlling for gender, marital status, education level, and occupation, the older age group over 40 years had a higher odds of seropositivity than the younger age group (OR 3.0 [95% CI 1.1-8.5]) in the final survey. Pupils or students had 3.3-fold increased odds of seropositivity (OR 3.2 [95% CI 1.1-8.5]) compared to the unemployed. This study reinforces that, SARS-CoV-2 infections have been significantly higher than reported.
%$ 052 ; 050