@article{fdi:010087103,
  title = {{T}he impact of food availability on tumorigenesis is evolutionarily conserved [+ correction, vol. 13, 22819, 2023]},
  author = {{T}issot, {S}. and {G}uimard, {L}. and {M}eliani, {J}. and {B}outry, {J}. and {D}ujon, {A}.{M}. and {C}app, {J}.{P}. and {T}{\¨o}k{\¨o}lyi, {J}. and {B}iro, {P}.{A}. and {B}eckmann, {C}. and {F}ontenille, {L}. and {D}o {K}hoa, {N}. and {H}amede, {R}. and {R}oche, {B}enjamin and {U}jvari, {B}. and {N}edelcu, {A}.{M}. and {T}homas, {F}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he inability to control cell proliferation results in the formation of tumors in many multicellular lineages. {N}onetheless, little is known about the extent of conservation of the biological traits and ecological factors that promote or inhibit tumorigenesis across the metazoan tree. {P}articularly, changes in food availability have been linked to increased cancer incidence in humans, as an outcome of evolutionary mismatch. {H}ere, we apply evolutionary oncology principles to test whether food availability, regardless of the multicellular lineage considered, has an impact on tumorigenesis. {W}e used two phylogenetically unrelated model systems, the cnidarian {H}ydra oligactis and the fish {D}anio rerio, to investigate the impact of resource availability on tumor occurrence and progression. {I}ndividuals from healthy and tumor-prone lines were placed on four diets that differed in feeding frequency and quantity. {F}or both models, frequent overfeeding favored tumor emergence, while lean diets appeared more protective. {I}n terms of tumor progression, high food availability promoted it, whereas low resources controlled it, but without having a curative effect. {W}e discuss our results in light of current ideas about the possible conservation of basic processes governing cancer in metazoans (including ancestral life history trade-offs at the cell level) and in the framework of evolutionary medicine.},
  keywords = {},
  booktitle = {},
  journal = {{S}cientific {R}eports},
  volume = {13},
  numero = {1},
  pages = {19825 [+ correction, 1 ]},
  ISSN = {2045-2322},
  year = {2023},
  DOI = {10.1038/s41598-023-46896-1},
  URL = {https://www.documentation.ird.fr/hor/fdi:010087103},
}