@article{fdi:010086978,
  title = {{N}umber of lifetime menses increases breast cancer occurrence in postmenopausal women at high familial risk},
  author = {{B}ieuville, {M}. and {F}augere, {D}. and {G}alibert, {V}. and {H}enard, {M}. and {D}ujon, {A}. {M}. and {U}jvari, {B}. and {P}ujol, {P}. and {R}oche, {B}enjamin and {T}homas, {F}.},
  editor = {},
  language = {{ENG}},
  abstract = {{I}t is increasingly thought that part of human susceptibility to cancer is the result of evolutionary mismatches: our ancestors evolved cancer suppression mechanisms in a world largely different from our modern environments. {I}n that context, it has been shown in cohorts from general {W}estern populations that reproductive traits modulate breast cancer risk. {O}verall, the more menses women experience, the more at risk they are to develop postmenopausal breast cancer. {T}his points towards an evolutionary mismatch but brings the question whether the reproductive pattern also modulates the breast cancer risk in menopausal women at high familial risk. {W}e thus studied the influence of menses on breast cancer risk in a case-control study of 90 postmenopausal women (including {BRCA}1/2 and non {BRCA}1/2) nested within a cohort at high familial risk. {W}e tested the association of the lifetime number of menses and the number of menses before first full-term pregnancy with postmenopausal breast cancer risk using {C}ox survival models. {W}e showed that the total lifetime number of menses was significantly associated with postmenopausal breast cancer risk and associated with a quicker onset of breast cancer after menopause. {T}hose results align with similar studies lead in general cohorts and suggest that the reproductive pattern modulates the familial risk of developing breast cancer after menopause. {A}ltogether, those results impact how we envision breast cancer prevention and call for more research on how ecological and genetic factors shape breast cancer risk.},
  keywords = {evolutionary mismatch ; breast cancer ; reproductive pattern ; survival ; models ; menopause ; {FRANCE}},
  booktitle = {},
  journal = {{F}rontiers in {E}cology and {E}volution},
  volume = {11},
  numero = {},
  pages = {912083 [9 ]},
  ISSN = {2296-701{X}},
  year = {2023},
  DOI = {10.3389/fevo.2023.912083},
  URL = {https://www.documentation.ird.fr/hor/fdi:010086978},
}