@article{fdi:010086969,
  title = {{P}rospective multicentre study of host response signatures in neonatal sepsis in {S}ub {S}aharan {A}frica},
  author = {{E}zinmegnon, {S}. and {M}ommert, {M}. and {B}artolo, {F}. and {A}gbota, {G}ino and {D}arius, {S}. and {B}riand, {V}al{\'e}rie and d'{A}lmeida, {M}. and {A}lao, {M}. {J}. and {D}ossou-{D}agba, {I}. and {M}assougbodji, {A}. and {L}austen-{T}homsen, {U}. and {P}achot, {A}. and {V}achot, {L}. and {Y}ugueros-{M}arcos, {J}. and {B}rengel-{P}esce, {K}. and {F}ievet, {N}adine and {T}issieres, {P}.},
  editor = {},
  language = {{ENG}},
  abstract = {{F}ew biomarkers for sepsis diagnosis are commonly used in neonatal sepsis. {W}hile the role of host response is increasingly recognized in sepsis pathogenesis and prognosis, there is a need for evaluating new biomarkers targeting host response in regions where sepsis burden is high and medico-economic resources are scarce. {T}he objective of the study is to evaluate diagnostic and prognostic accuracy of biomarkers of neonatal sepsis in {S}ub {S}aharan {A}frica. {T}his prospective multicentre study included newborn infants delivered in the {A}bomey-{C}alavi region in {S}outh {B}enin and their follow-up from birth to 3 months of age. {A}ccuracy of transcriptional ({CD}74, {CX}3{CR}1), proteic ({PCT}, {IL}-6, {IL}-10, {IP}-10) biomarkers and clinical characteristics to diagnose and prognose neonatal sepsis were measured. {A}t delivery, cord blood from all consecutive newborns were sampled and analysed, and infants were followed for a 12 weeks' period. {F}ive hundred and eighty-one newborns were enrolled. {O}ne hundred and seventy-two newborns developed neonatal sepsis (29.6%) and death occurred in forty-nine infants (8.4%). {A}lthough {PCT}, {IL}-6 and {IP}-10 levels were independently associated with sepsis diagnosis, diagnostic accuracy of clinical variables combinations was similar to combinations with biomarkers and superior to biomarkers alone. {N}onetheless, {CD}74, being the only biomarkers independently associated with mortality, showed elevated prognosis accuracy ({AUC}>0.9) either alone or in combination with other biomarkers (eg. {CD}74/{IP}-10) or clinical criterion (eg. {A}pgar 1, birth weight). {T}hese results suggest that cord blood {PCT} had a low accuracy for diagnosing early onset neonatal sepsis in {S}ub {S}aharan {A}frican neonates, while association of clinical criterion showed to be more accurate than any biomarkers taken independently. {A}t birth, {CD}74, either associated with {IP}-10 or clinical criterion, had the best accuracy in prognosing sepsis mortality.{T}rial registration {C}linicaltrial.gov registration number: {NCT}03780712. {R}egistered 19 {D}ecember 2018. {R}etrospectively registered.},
  keywords = {{BENIN}},
  booktitle = {},
  journal = {{S}cientific {R}eports - {N}ature},
  volume = {12},
  numero = {1},
  pages = {21458 [17 p.]},
  ISSN = {2045-2322},
  year = {2022},
  DOI = {10.1038/s41598-022-25892-x},
  URL = {https://www.documentation.ird.fr/hor/fdi:010086969},
}