@article{fdi:010086968,
  title = {{H}uman {T}-{L}ymphotropic virus type 1 and human immunodeficiency virus co-infection in rural {G}abon},
  author = {{M}ouinga-{O}ndeme, {A}. and {B}oundenga, {L}. and {K}oumba, {I}. {P}. {K}. and {M}amimandjiami, {A}. {I}. and {D}iane, {A}. and {E}ngone-{O}ndo, {J}. {D}. and {D}juicy, {D}. {D}. and {S}ica, {J}. and {M}ombo, {L}. {E}. and {G}essain, {A}. and {A}ghokeng {F}obang, {A}velin},
  editor = {},
  language = {{ENG}},
  abstract = {{I}ntroduction {H}uman {T}-cell lymphotrophic virus type-1 ({HTLV}-1) and human immunodeficiency virus ({HIV}-1) co-infection occur in many populations. {P}eople living with {HIV}-1 and infected with {HTLV}-1 seem more likely to progress rapidly towards {AIDS}. {B}oth {HTLV}-1 and {HIV}-1 are endemic in {G}abon ({C}entral {A}frica). {W}e investigated {HTLV}-1 and {HIV}-1 co-infection in the {H}aut-{O}gooue province, and assessed factors that may favor the rapid evolution and progression to {AIDS} in co-infected patients. {M}ethods {P}lasma samples from {HTLV}-1 patients were tested using {ELISA}, and positive samples were then tested by western blot assay ({WB}). {W}e used the polymerase chain reaction to detect {HTLV}-1 {T}ax/{R}ex genes using {DNA} extracted from the buffy coat of {ELISA}-positives samples. {R}esults {W}e recruited 299 individuals (mean age 46 years) including 90 (30%) men and 209 (70%) women, all of whom are under treatment at the {A}mbulatory {T}reatment {C}entre of the province. {O}f these, 45 were {ELISA} {HTLV}-1/2 seropositive. {A}ccording to {WB} criteria, 21 of 45 were confirmed positive: 20 were {HTLV}-1 (44%), 1 was {HTLV}-1/2 (2%), 2 were indeterminate (4%) and 22 were seronegative (49%). {PCR} results showed that 23 individuals were positive for the {T}ax/{R}ex region. {C}onsidering both serological and molecular assays, the prevalence of {HTLV}-1 infection was estimated at 7.7%. {B}eing a woman and increasing age were found to be independent risk factors for co-infection. {M}ean {CD}4+ cell counts were higher in {HTLV}-1/{HIV}-1 co-infected (578.1 ( 340.8) cells/mm(3)) than in {HIV}-1 mono-infected (481.0 (+/- 299.0) cells/mm(3)) {I}ndividuals. {S}imilarly, the mean {HIV}-1 viral load was {L}og 3.0 (+/- 1.6) copies/ml in mono-infected and {L}og 2.3 (+/- 0.7) copies/ml in coinfected individuals. {C}onclusion {W}e described an overall high prevalence of {HTLV}-1/{HIV}-1 co-infection in {G}abon. {O}ur findings stress the need of strategies to prevent and manage these co-infections.},
  keywords = {{GABON}},
  booktitle = {},
  journal = {{PL}o{S} {O}ne},
  volume = {17},
  numero = {7},
  pages = {e0271320 [11 p.]},
  ISSN = {1932-6203},
  year = {2022},
  DOI = {10.1371/journal.pone.0271320},
  URL = {https://www.documentation.ird.fr/hor/fdi:010086968},
}