@article{fdi:010086967,
  title = {{N}atural plant diet impacts phenotypic expression of pyrethroid resistance in {A}nopheles mosquitoes},
  author = {{P}ar{\'e}, {P}. {S}. {L}. and {H}ien, {D}fds and {B}ayili, {K}. and {Y}erbanga, {R}. {S}. and {C}ohuet, {A}nna and {C}arrasco, {D}avid and {G}uissou, {E}. and {G}ouagna, {L}ouis-{C}l{\'e}ment and {Y}ameogo, {K}. {B}. and {D}iabate, {A}. and {I}gnell, {R}. and {D}abir{\'e}, {R}. {K}. and {L}ef{\`e}vre, {T}hierry and {G}nankin{\'e}, {O}.},
  editor = {},
  language = {{ENG}},
  abstract = {{S}uccess in reducing malaria transmission through vector control is threatened by insecticide resistance in mosquitoes. {A}lthough the proximal molecular mechanisms and genetic determinants involved are well documented, little is known about the influence of the environment on mosquito resistance to insecticides. {T}he aim of this study was to assess the effect of plant sugar feeding on the response of {A}nopheles gambiae sensu lato to insecticides. {A}dults were fed with one of four treatments, namely a 5% glucose control solution, nectariferous flowers of {B}arleria lupulina, of {C}ascabela thevetia and a combination of both {B}. lupulina+{C}. thevetia. {WHO} tube tests were performed with 0.05% and 0.5% deltamethrin, and knockdown rate ({KD}) and the 24 h mosquito mortality were measured. {P}lant diet significantly influenced mosquito {KD} rate at both concentrations of deltamethrin. {F}ollowing exposure to 0.05% deltamethrin, the {B}. lupulina diet induced a 2.5 fold-increase in mosquito mortality compared to 5% glucose. {S}pecies molecular identification confirmed the predominance of {A}n. gambiae (60% of the samples) over {A}n. coluzzii and {A}n. arabiensis in our study area. {T}he kdr mutation {L}1014{F} displayed an allelic frequency of 0.75 and was positively associated with increased phenotypic resistance to deltamethrin. {P}lant diet, particularly {B}. lupulina, increased the susceptibility of mosquitoes to insecticides. {T}he finding that {B}. lupulina-fed control individuals (i.e. not exposed to deltamethrin) also displayed increased 24 h mortality suggests that plant-mediated effects may be driven by a direct effect of plant diet on mosquito survival rather than indirect effects through interference with insecticide-resistance mechanisms. {T}hus, some plant species may weaken mosquitoes, making them less vigorous and more vulnerable to the insecticide. {T}here is a need for further investigation, using a wider range of plant species and insecticides, in combination with other relevant environmental factors, to better understand the expression and evolution of insecticide resistance.},
  keywords = {{BURKINA} {FASO}},
  booktitle = {},
  journal = {{S}cientific {R}eports - {N}ature},
  volume = {12},
  numero = {1},
  pages = {21431 [10 p.]},
  ISSN = {2045-2322},
  year = {2022},
  DOI = {10.1038/s41598-022-25681-6},
  URL = {https://www.documentation.ird.fr/hor/fdi:010086967},
}