%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Somda, M. B.
%A N'Djetchi, M. K.
%A Kaboré, J.
%A Ilboudo, H.
%A Dama, E.
%A Boma, S.
%A Courtin, Fabrice
%A Poinsignon, Anne
%A Bengaly, Z.
%A Remoué, Franck
%A Belem, A. M. G.
%A Bucheton, Bruno
%A Jamonneau, Vincent
%A Koffi, M.
%T Evaluation of antibody responses to tsetse fly saliva in domestic animals in the sleeping sickness endemic foci of Bonon and Sinfra, Cote d'Ivoire
%D 2022
%L fdi:010086951
%G ENG
%J Veterinary Parasitology : Regional Studies and Reports
%@ 2405-9390
%K Trypanosoma brucei gambiense ; Animal reservoirs ; Tsetse fly ; Biomarker of exposure ; Cote d'Ivoire
%K COTE D'IVOIRE
%M ISI:000931807200011
%P 100773 [5 ]
%R 10.1016/j.vprsr.2022.100773
%U https://www.documentation.ird.fr/hor/fdi:010086951
%> https://www.documentation.ird.fr/intranet/publi/2023-04/010086951.pdf
%V 34
%W Horizon (IRD)
%X After intensive control efforts, human African trypanosomiasis (HAT) was declared eliminated in Cote d'Ivoire as a public health problem in December 2020 and the current objective is to achieve the interruption of the transmission (zero cases). Reaching this objective could be hindered by the existence of an animal reservoir of Trypanosoma (T.) brucei (b.) gambiense. In the framework of a study led in 2013 to assess the role of domestic animals in the epidemiology of HAT in the two last active foci from Cote d'Ivoire (Bonon and Sinfra), plasmas were sampled from four species of domestic animals for parasitological (microscopic examination by the buffy coat technique (BCT)), serological (immune trypanolysis (TL)) and molecular (specific PCR: TBR for T. brucei s.l., TCF for T. congolense forest type, TVW for T. vivax and PCR for T. b. gambiense) testing. In order to improve the understanding of the involvement/role of these animals in the transmission of T. b. gambiense, we have quantified in this study the IgG response to whole saliva extracts of Glossina palpalis gambiensis in order to perform an association analysis between anti-saliva responses and the positivity of diagnostic tests. Cattle and pigs had significantly higher rates of anti-tsetse saliva responses compared to goats and sheep (p < 0.01). In addition, the anti-tsetse saliva responses were strongly associated with the parasitology (BCT+), serology (TL+) and PCR (TBR+ and TCF+) results (p < 0.001). These associations indicate a high level of contacts between the positive/ infected animals and tsetse flies. Our findings suggest that protecting cattle and pigs against tsetse bites could have a significant impact in reducing transmission of both animal and human trypanosome species, and advocates for a "One health" approach to better control African trypanosomosis in Cote d'Ivoire.
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