@article{fdi:010086948,
  title = {{N}onconcomitant host-to-host transmission of multipartite virus genome segments may lead to complete genome reconstitution},
  author = {{D}i {M}attia, {J}. and {T}orralba, {B}. and {Y}von, {M}. and {Z}eddam, {J}ean-{L}ouis and {B}lanc, {S}. and {M}ichalakis, {Y}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ecause multipartite viruses package their genome segments in different viral particles, they face a potentially huge cost if the entire genomic information, i.e., all genome segments, needs to be present concomitantly for the infection to function. {P}revious work with the octapartite faba bean necrotic stunt virus ({FBNSV}; family {N}anoviridae, genus {N}anovirus) showed that this issue can be resolved at the within-host level through a supracellular functioning; all viral segments do not need to be present within the same host cell but may complement each other through intercellular trafficking of their products (protein or messenger {RNA} [m{RNA}]). {H}ere, we report on whether {FBNSV} can as well decrease the genomic integrity cost during between-host transmission. {U}sing viable infections lacking nonessential virus segments, we show that full-genome infections can be reconstituted and function through separate acquisition and/or inoculation of complementary sets of genome segments in recipient hosts. {T}his separate acquisition/inoculation can occur either through the transmission of different segment sets by different individual aphid vectors or by the sequential acquisition by the same aphid of complementary sets of segments from different hosts. {T}he possibility of a separate between-host transmission of different genome segments thus offers a way to at least partially resolve the genomic maintenance problem faced by multipartite viruses.},
  keywords = {multipartite virus ; virus transmission ; genome architecture},
  booktitle = {},
  journal = {{P}roceedings of the {N}ational {A}cademy of {S}ciences of the {U}nited {S}tates of {A}merica},
  volume = {119},
  numero = {32},
  pages = {e2201453119 [9 p.]},
  ISSN = {0027-8424},
  year = {2022},
  DOI = {10.1073/pnas.2201453119},
  URL = {https://www.documentation.ird.fr/hor/fdi:010086948},
}