@article{fdi:010086933,
  title = {{R}ate of virological failure and {HIV}-1 drug resistance among {HIV}-infected adolescents in routine follow-up on health facilities in {C}ameroon},
  author = {{P}enda, {C}. {I}. and {M}bonjo, {M}. {M}. and {F}okam, {J}. and {D}jeuda, {A}. {B}. {D}. and {G}race, {N}. and {N}dongo, {F}. {A}. and {B}ilong, {S}. and {B}ille, {B}. {E}. and {N}dombo, {P}. {K}. and {A}ghokeng {F}obang, {A}velin and {N}djolo, {A}. and {M}oukoko, {C}. {E}. {E}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he objective of this study was to determine the rates of virological failure ({VF}) and {HIV} drug resistance ({HIVDR}) amongst adolescents on antiretroviral {T}herapy ({ART}). {A} retrospectively designed study was conducted in 10 healthcare centers for adolescents living with {HIV} ({ALHIV}) in the two main cities of {C}ameroon ({Y}aounde and {D}ouala), from {N}ovember 2018 to {M}ay 2019. {S}ociodemographic, clinical, therapeutic and laboratory parameters were collected from medical records. {A}ll enrolled {ALHIV} had viral load ({VL}) measurements following the national guidelines. {A}ll patients with a {VL} >= 1000 copies/ml were called to perform genotyping tests. {T}he chi-square test was used to determine the factors associated with {VF}. {O}ut of the 1316 medical records of {ALHIV}, we included 1083 {ALHIV} having a {VL} result. {A}mong them, 276 (25.5%) were experiencing {VF}, and {VF} was significantly higher in {ALHIV} with suboptimal adherence (p<0.001), older adolescents (p<0.05), those who lived outside the city where they were receiving {ART} (p<0.006), severely immunocompromised (p<0.01) and started {ART} at infancy (p<0.02). {A}mong the 45/276 (16.3%) participants with an available genotyping resistance testing ({GRT}) result, the overall rate of {HIVDR} was 93.3% (42/45). {T}he most common mutations were {K}103{N} (n = 21/42, 52.3%) resulting in high-level resistance to {E}favirenz and {N}evirapine, followed by {M}184{V} (n = 20/42, 47.6%) and thymidine analog mutations (n = 15/42, 35.7%) associated with high-level resistance to {L}amivudine and {Z}idovudine respectively. {T}he high rate of {VF} and {HIVDR} among {ALHIV} regularly followed in health facilities in {C}ameroon highlights the need to develop interventions adapted to an adolescent-centered approach to preserve future {ART} options.},
  keywords = {{CAMEROUN}},
  booktitle = {},
  journal = {{PL}o{S} {O}ne},
  volume = {17},
  numero = {10},
  pages = {e0276730 [14 p.]},
  ISSN = {1932-6203},
  year = {2022},
  DOI = {10.1371/journal.pone.0276730},
  URL = {https://www.documentation.ird.fr/hor/fdi:010086933},
}