@article{fdi:010086901,
  title = {{G}enetic diversity and molecular epidemiology of {M}iddle {E}ast {R}espiratory {S}yndrome {C}oronavirus in dromedaries in {E}thiopia, 2017-2020},
  author = {{Z}hou, {Z}. {Q}. and {A}li, {A}. and {W}alelign, {E}. and {D}emissie, {G}. {F}. and {E}l {M}asry, {I}. and {A}bayneh, {T}. and {G}etachew, {B}. and {K}rishnan, {P}. and {N}g, {D}. {Y}. {M}. and {G}ardner, {E}. and {M}akonnen, {Y}. and {M}iguel, {E}ve and {C}hevalier, {V}. and {C}hu, {D}. {N}. {K}. and {S}o, {R}. {T}. {Y}. and {V}on {D}obschuetz, {S}. and {M}amo, {G}. and {P}oon, {L}. {L}. {M}. and {P}eiris, {M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{M}iddle {E}ast respiratory syndrome coronavirus ({MERS}-{C}o{V}) is enzootic in dromedary camels and causes zoonotic infection and disease in humans. {A}lthough over 80% of the global population of infected dromedary camels are found in {A}frica, zoonotic disease had only been reported in the {A}rabia {P}eninsula and travel-associated disease has been reported elsewhere. {I}n this study, genetic diversity and molecular epidemiology of {MERS}-{C}o{V} in dromedary camels in {E}thiopia were investigated during 2017-2020. {O}f 1766 nasal swab samples collected, 61 (3.5%) were detected positive for {MERS}-{C}o{V} {RNA}. {O}f 484 turbinate swab samples collected, 10 (2.1%) were detected positive for {MERS}-{C}o{V} {RNA}. {T}wenty-five whole genome sequences were obtained from these {MERS}-{C}o{V} positive samples. {P}hylogenetically, these {E}thiopian camel-originated {MERS}-{C}o{V} belonged to clade {C}2, clustering with other {E}ast {A}frican camel strains. {V}irus sequences from camel herds clustered geographically while in an abattoir, two distinct phylogenetic clusters of {MERS}-{C}o{V}s were observed in two sequential sampling collections, which indicates the greater genetic diversity of {MERS}-{C}o{V} in abattoirs. {I}n contrast to clade {A} and {B} viruses from the {A}rabian {P}eninsula, clade {C} camel-originated {MERS}-{C}o{V} from {E}thiopia had various nucleotide insertions and deletions in non-structural gene nsp3, accessory genes {ORF}3 and {ORF}5 and structural gene {N}. {T}his study demonstrates the genetic instability of {MERS}-{C}o{V} in dromedaries in {E}ast {A}frica, which indicates that the virus is still actively adapting to its camel host. {T}he impact of the observed nucleotide insertions and deletions on virus evolution, viral fitness, and zoonotic potential deserves further study.},
  keywords = {{MERS}-{C}o{V} ; {E}thiopia ; genetic instability ; molecular epidemiology ; evolution ; {ETHIOPIE}},
  booktitle = {},
  journal = {{E}merging {M}icrobes and {I}nfections},
  volume = {12},
  numero = {1},
  pages = {e2164218 [9 p.]},
  year = {2023},
  DOI = {10.1080/22221751.2022.2164218},
  URL = {https://www.documentation.ird.fr/hor/fdi:010086901},
}