@article{fdi:010086891,
  title = {{D}istinct loiasis infection states and associated clinical and hematological manifestations in patients from {G}abon},
  author = {{V}eletzky, {L}. and {E}berhardt, {K}. {A}. and {H}ergeth, {J}. and {S}telzl, {D}. {R}. and {M}anego, {R}. {Z}. and {M}ombo-{N}goma, {G}. and {K}reuzmair, {R}. and {B}urger, {G}. and {A}degnika, {A}. {A}. and {A}gnandji, {S}. {T}. and {M}atsiegui, {P}. {B}. and {B}oussinesq, {M}ichel and {M}ordmuller, {B}. and {R}amharter, {M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground {L}oiasis-a filarial disease endemic in {C}entral and {W}est {A}frica-is increasingly recognized as significant individual and public health concern. {W}hile the understanding of the disease characteristics remains limited, significant morbidity and excess mortality have been demonstrated. {H}ere, we characterize clinical and hematological findings in a large cohort from {G}abon. {M}ethods {L}oiasis-related clinical manifestations and microfilaremia, hemoglobin and differential blood counts were recorded prospectively during a cross-sectional survey. {F}or analysis, participants were categorized into distinct infection states by the diagnostic criteria of eye worm history and microfilaremia. {R}esults {A}nalysis of data from 1,232 individuals showed that occurrence of clinical and hematological findings differed significantly between the infection states. {E}ye worm positivity was associated with a wide range of clinical manifestations while microfilaremia by itself was not. {L}oa loa infection was associated with presence of eosinophilia and absolute eosinophil counts were associated with extent of microfilaremia (p-adj. = 0.012, beta-estimate:0.17[0.04-0.31]). {C}onclusions {L}oiasis is a complex disease, causing different disease manifestations in patients from endemic regions. {T}he consequences for the affected individuals or populations as well as the pathophysiological consequences of correlating eosinophilia are largely unknown. {H}igh-quality research on loiasis should be fostered to improve patient care and understanding of the disease.},
  keywords = {{GABON}},
  booktitle = {},
  journal = {{PL}o{S} {N}eglected {T}ropical {D}iseases},
  volume = {16},
  numero = {9},
  pages = {e0010793 [15 p.]},
  ISSN = {1935-2735},
  year = {2022},
  DOI = {10.1371/journal.pntd.0010793},
  URL = {https://www.documentation.ird.fr/hor/fdi:010086891},
}