Factors associated with COVID-19 vaccine intention in Benin in 2021 : a cross-sectional study Avahoundje, E. M. Dossou, J. P. Vigan, A. Gaye, I. Agossou, C. Boyi, C. Bello, K. Mikponhoue, J. Ba, M. F. Faye, A. /Ridde, Valéry Benin COVID-19 Intention Vaccine Introduction: The development of COVID-19 vaccines has brought considerable hope for the control of the pandemic. With a view to promoting good vaccine coverage, this study aimed to measure vaccine inten-tion against COVID-19 and to understand the factors that promote it. Method: In April 2021, we conducted a cross-sectional and analytical study at the national level through a telephone survey of Beninese aged 18 years or older. We used a marginal quota sampling method (n = 865) according to age, gender, and department. We constructed the questionnaire using a theoretical framework of health intention. We determined the factors associated with intention to vaccinate against COVID-19 in Benin using a multinomial logistic regression at the 5 % significance level.Results: The intention to vaccinate was 64.7 %; 10.9 % of the population were hesitant, and 24.4 % did not want to vaccinate. Thinking that it was important to get vaccinated (AOR = 0.274; CI = 0.118-0.638) or that getting vaccinated will help protect loved ones from the virus (AOR = 0.399; CI = 0.205-0.775) increased the intention to vaccinate. Having a high level of education (AOR = 1.988; CI = 1.134-3.484), thinking that the vaccine could put one's health at risk (AOR = 2.259; CI = 1.114-4.578), and hearing something negative about the vaccine (AOR = 1.765; CI = 1.059-2.941) reduced intention to vaccinate. In addition, believing that the creators of the vaccine had ensured its safety (AOR = 0.209; CI = 0.101- 0.430), and believing that it was unlikely to be infected after vaccination (AOR = 0.359; CI = 0.183- 0.703) decreased hesitancy in favour of the intention to vaccinate. Conclusion: In April 2021, vaccine intention was high, but maintaining this high rate requires building confidence in the vaccine and combating misinformation about the vaccine. 2022 text https://www.documentation.ird.fr/hor/fdi:010086758 fdi:010086758 Avahoundje E. M., Dossou J. P., Vigan A., Gaye I., Agossou C., Boyi C., Bello K., Mikponhoue J., Ba M. F., Faye A., Ridde Valéry. Factors associated with COVID-19 vaccine intention in Benin in 2021 : a cross-sectional study. 2022, 12, 100237 [9 ] EN BENIN