@article{fdi:010086752,
  title = {{T}uberculosis infection in children and adolescents},
  author = {{Y}oungui, {B}. {T}. and {T}chounga, {B}. {K}. and {G}raham, {S}. {M}. and {B}onnet, {M}aryline},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he burden of tuberculosis ({TB}) in children and adolescents remains very significant. {S}everal million children and adolescents are infected with {TB} each year worldwide following exposure to an infectious {TB} case and the risk of progression from {TB} infection to tuberculosis disease is higher in this group compared to adults. {T}his review describes the risk factors for {TB} infection in children and adolescents. {F}ollowing {TB} exposure, the risk of {TB} infection is determined by a combination of index case characteristics, contact features, and environmental determinants. {W}e also present the recently recommended approaches to diagnose and treat {TB} infection as well as novel tests for infection. {T}he tests for {TB} infection have limitations and diagnosis still relies on an indirect immunological assessment of cellular immune response to {M}ycobacterium tuberculosis antigens using immunodiagnostic testing. {I}t is recommended that {TB} exposed children and adolescents and those living with {HIV} receive {TB} preventive treatment ({TPT}) to reduce the risk of progression to {TB} disease. {S}everal {TPT} regimens of similar effectiveness and safety are now available and recommended by the {W}orld {H}ealth {O}rganisation.},
  keywords = {tuberculosis infection ; children ; adolescents ; {MONDE}},
  booktitle = {},
  journal = {{P}athogens},
  volume = {11},
  numero = {12},
  pages = {1512 [14 p.]},
  year = {2022},
  DOI = {10.3390/pathogens11121512},
  URL = {https://www.documentation.ird.fr/hor/fdi:010086752},
}