@article{fdi:010086742,
  title = {{M}ultidrug-resistant enterobacterales in community-acquired urinary tract infections in {D}jibouti, {R}epublic of {D}jibouti},
  author = {{M}ohamed, {H}. {S}. and {A}boubaker, {M}. {H}. and {D}umont, {Y}. and {D}idelot, {M}. {N}. and {M}ichon, {A}. {L}. and {G}alal, {L}okman and {J}ean-{P}ierre, {H}. and {G}odreuil, {S}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he emergence and spread of multidrug resistant {E}nterobacterales ({MDR}-{E}) are a global public health issue. {T}his problem also concerns urinary tract infections ({UTI}), which are the second most frequent infections after respiratory infections. {T}he objective of this study was to determine {MDR}-{E} frequency and to characterize {MDR}-{E} isolates from patients with community-acquired {UTI}s in {D}jibouti, {R}epublic of {D}jibouti. {F}rom 800 clinical urinary samples collected at the {M}er {R}ouge {L}aboratory, {D}jibouti, from {J}anuary to {J}uly 2019, 142 were identified as {E}nterobacterales (age range of the 142 patients mean age is 42 years.) {M}ass spectrometry analysis of these isolates identified 117 {E}scherichia coli, 14 {K}lebsiella pneumoniae, 2 {P}roteus mirabilis, 4 {E}nterobacter spp., 4 {P}rovidencia stuartii and 1 {F}ranconibacter helveticus. {A}ntibiotic susceptibility testing (disk diffusion method) of these 142 isolates detected 68 {MDR}-{E} (68/142 = 48%): 65 extended-spectrum beta lactamase- ({ESBL}), 2 carbapenemase- (one also {ESBL}), and 1 cephalosporinase-producer. {M}ultiplex {PCR} and sequencing showed that the 65 {ESBL}-producing isolates carried genes encoding {CTX}-{M} enzymes ({CTX}-{M}-15 in 97% and {CTX}-{M}-9 in 3% of isolates). {T}wo isolates harboured a gene encoding the {OXA}-48-like carbapenemase, and one the gene encoding the {A}mp{C} {CMY}-2 cephalosporinase. {G}enes implicated in resistance to quinolones (qnr{B}, aac (6 ')-{I}b-cr, qnr{D}, oqx{A} and {B}) also were detected. {A}mong the {E}. coli phylogroups, {B}2 was the most common phylogenetic group (21% of {MDR}-{E} isolates and 26% of non-{MDR}-{E} isolates), followed by {A} (14% and 12%), {B}1 (9% and 7%), {D} (3% and 3%), {F} (3% and 3%) and {E} (2% and 2%). {T}his study highlights the high frequency of {ESBL} producers and the emergence of carbapenemase-producers among {E}nterobacterales causing community-acquired {UTI}s in {D}jibouti.},
  keywords = {urinary tract infections ; {E}nterobacterales ; extended-spectrum ; beta-lactamase carbapenemases ; community ; {D}jibouti ; {DJIBOUTI}},
  booktitle = {},
  journal = {{A}ntibiotics},
  volume = {11},
  numero = {12},
  pages = {1740 [10 ]},
  ISSN = {2079-6382},
  year = {2022},
  DOI = {10.3390/antibiotics11121740},
  URL = {https://www.documentation.ird.fr/hor/fdi:010086742},
}