%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Fall, A. K.D. J.
%A Courtin, David
%A Adamou, R.
%A Edslev, S.
%A Hansen, A.
%A Domingo, N.
%A Christiansen, M.
%A Adu, B.
%A Milet, Jacqueline
%A Garcia, André
%A Theisen, M.
%A Migot Nabias, Florence
%A Dechavanne, Célia
%T Fc gamma receptor IIIB NA1/NA2/SH polymorphisms are associated with malaria susceptibility and antibody levels to P. falciparum merozoite antigens in Beninese children
%D 2022
%L fdi:010086718
%G ENG
%J International Journal of Molecular Sciences
%@ 1422-0067
%K Fc gamma receptor ; FcgRIIIB-NA1 ; -NA2 ; -SH variants ; malaria ; susceptibility ; antibody response ; Benin
%K BENIN
%M ISI:000896082200001
%N 23
%P 14882 [14 ]
%R 10.3390/ijms232314882
%U https://www.documentation.ird.fr/hor/fdi:010086718
%> https://horizon.documentation.ird.fr/exl-doc/pleins_textes/2023-01/010086718.pdf
%V 23
%W Horizon (IRD)
%X This paper aimed to investigate the influence of polymorphisms in the FCGR2A gene encoding R131H FcgRIIA variants and in the FCGR3B gene (108G > C, 114C > T, 194 A > G, 233C > A, 244 G > A and 316G > A) encoding FcgRIIIB-NA1, -NA2 and -SH variants on malaria susceptibility and antibody responses against P. falciparum merozoite antigens in Beninese children. An active malaria follow-up was conducted in infants from birth to 24 months of age in Allada, Benin. FCGR3B exon 3 was sequenced and FCGR2A exon 4 was genotyped. Antibodies directed to GLURP and MSP3 were quantified by ELISA. Association studies were performed using mixed-effect models. Individual carriage of FCGR3B 194 AA genotype was associated with a high number of malaria infections and a low level of IgG1 against MSP3 and GLURP-R0. High parasitemia and increased malaria infections were observed in infants carrying the FCGR3B*05 108C-114T-194A-233C-244A-316A haplotype. A reduced risk of malaria infections and low parasitemia were related to the carriages of the FCGR3B 108C-114T-194G-233C-244G-316A (FCGR3B*06), FCGR3B 108C-114T-194G-233A-244A-316A (FCGR3B*03 encoding for FcgRIIIB-SH) haplotypes and FCGR3B 297 TT genotype. Our results highlight the impact of FCGR3B polymorphisms on the individual susceptibility to malaria and antibody responses against MSP3 and GLURP in Beninese children.
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