@article{fdi:010086718,
  title = {{F}c gamma receptor {IIIB} {NA}1/{NA}2/{SH} polymorphisms are associated with malaria susceptibility and antibody levels to {P}. falciparum merozoite antigens in {B}eninese children},
  author = {{F}all, {A}. {K}.{D}. {J}. and {C}ourtin, {D}avid and {A}damou, {R}. and {E}dslev, {S}. and {H}ansen, {A}. and {D}omingo, {N}. and {C}hristiansen, {M}. and {A}du, {B}. and {M}ilet, {J}acqueline and {G}arcia, {A}ndr{\'e} and {T}heisen, {M}. and {M}igot {N}abias, {F}lorence and {D}echavanne, {C}{\'e}lia},
  editor = {},
  language = {{ENG}},
  abstract = {{T}his paper aimed to investigate the influence of polymorphisms in the {FCGR}2{A} gene encoding {R}131{H} {F}cg{RIIA} variants and in the {FCGR}3{B} gene (108{G} > {C}, 114{C} > {T}, 194 {A} > {G}, 233{C} > {A}, 244 {G} > {A} and 316{G} > {A}) encoding {F}cg{RIIIB}-{NA}1, -{NA}2 and -{SH} variants on malaria susceptibility and antibody responses against {P}. falciparum merozoite antigens in {B}eninese children. {A}n active malaria follow-up was conducted in infants from birth to 24 months of age in {A}llada, {B}enin. {FCGR}3{B} exon 3 was sequenced and {FCGR}2{A} exon 4 was genotyped. {A}ntibodies directed to {GLURP} and {MSP}3 were quantified by {ELISA}. {A}ssociation studies were performed using mixed-effect models. {I}ndividual carriage of {FCGR}3{B} 194 {AA} genotype was associated with a high number of malaria infections and a low level of {I}g{G}1 against {MSP}3 and {GLURP}-{R}0. {H}igh parasitemia and increased malaria infections were observed in infants carrying the {FCGR}3{B}*05 108{C}-114{T}-194{A}-233{C}-244{A}-316{A} haplotype. {A} reduced risk of malaria infections and low parasitemia were related to the carriages of the {FCGR}3{B} 108{C}-114{T}-194{G}-233{C}-244{G}-316{A} ({FCGR}3{B}*06), {FCGR}3{B} 108{C}-114{T}-194{G}-233{A}-244{A}-316{A} ({FCGR}3{B}*03 encoding for {F}cg{RIIIB}-{SH}) haplotypes and {FCGR}3{B} 297 {TT} genotype. {O}ur results highlight the impact of {FCGR}3{B} polymorphisms on the individual susceptibility to malaria and antibody responses against {MSP}3 and {GLURP} in {B}eninese children.},
  keywords = {{F}c gamma receptor ; {F}cg{RIIIB}-{NA}1 ; -{NA}2 ; -{SH} variants ; malaria ; susceptibility ; antibody response ; {B}enin ; {BENIN}},
  booktitle = {},
  journal = {{I}nternational {J}ournal of {M}olecular {S}ciences},
  volume = {23},
  numero = {23},
  pages = {14882 [14 ]},
  ISSN = {1422-0067},
  year = {2022},
  DOI = {10.3390/ijms232314882},
  URL = {https://www.documentation.ird.fr/hor/fdi:010086718},
}