@article{fdi:010086661,
  title = {{N}aturally acquired antibodies from {B}eninese infants promote {P}lasmodium falciparum merozoite-phagocytosis by human blood leukocytes : implications for control of asymptomatic malaria infections},
  author = {{F}all, {A}kdj and {K}ana, {I}. {H}. and {D}echavanne, {C}{\'e}lia and {G}arcia-{S}enosiain, {A}. and {G}uitard, {E}. and {M}ilet, {J}acqueline and {M}assougbodji, {A}. and {G}arcia, {A}ndr{\'e} and {D}ugoujon, {J}. {M}. and {M}igot {N}abias, {F}lorence and {T}heisen, {M}. and {C}ourtin, {D}avid},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground {I}mmunoglobulin {G} ({I}g{G}) antibodies are thought to play important roles in the protection against {P}lasmodium falciparum ({P}. falciparum) malaria. {A} longitudinal cohort study performed in the {S}outhern part of {B}enin, identified a group of infants who were able to control asymptomatic malaria infections ({CAIG}). {M}ethods {I}g{G} antibodies against distinct merozoite antigens were quantified in plasma from {B}eninese infants. {F}unctionality of these antibodies was assessed by the merozoite-phagocytosis assay using {THP}-1 cells and primary neutrophils as effector cells. {G}m allotypes were determined by a serological method of haemagglutination inhibition. {R}esults {P}urified {I}g{G} from infants in {CAIG} promoted higher levels of merozoite-phagocytosis than did {I}g{G} from children who were unable to control asymptomatic infections ({O}logit multivariate regression model, {C}oef. = 0.06, 95% {CI} 0.02;0.10, {P} = 0.002). {H}igh level of merozoite-phagocytosis activity was significantly associated with high levels of {I}g{G} against {AMA}1 ({C}oef. = 1.76, 95% {CI} 0.39;3.14, {P} = 0.012) and {GLURP}-{R}2 ({C}oef. = 12.24, 95% {CI} 1.35;23.12, {P} = 0.028). {M}oreover, infants of the {G}3m5,6,10,11,13,14,24 phenotype showed higher merozoite-phagocytosis activity ({G}eneralized linear model multivariate regression, {C}oef. = 7.46, 95% {CI} 0.31;14.61, {P} = 0.041) than those presenting other {G}3m phenotypes. {C}onclusion {T}he results of the present study confirm the importance of antibodies to merozoite surface antigens in the control of asymptomatic malaria infection in {B}eninese infants. {T}he study also demonstrated that {G}3m phenotypes impact the functional activity of {I}g{G}. {T}his last point could have a considerable impact in the research of candidate vaccines against malaria parasites or other pathogens.},
  keywords = {{I}g{G} ; {G}m allotypes ; {O}psonic phagocytosis ; {C}ontrol of asymptomatic malaria ; infection ; {B}enin ; {BENIN}},
  booktitle = {},
  journal = {{M}alaria {J}ournal},
  volume = {21},
  numero = {1},
  pages = {356 [15 ]},
  ISSN = {1475-2875},
  year = {2022},
  DOI = {10.1186/s12936-022-04361-w},
  URL = {https://www.documentation.ird.fr/hor/fdi:010086661},
}