@article{fdi:010086486,
  title = {{F}actors associated with the periodicity of {L}oa loa microfilaremia in the {R}epublic of the {C}ongo},
  author = {{C}ampillo, {J}{\'e}r{\'e}my and {L}ouya, {F}. and {B}ikita, {P}. and {M}issamou, {F}. and {P}ion, {S}{\'e}bastien and {B}oussinesq, {M}ichel and {C}hesnais, {C}{\'e}dric},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {L}oa loa microfilariae circulate in the peripheral blood of human hosts following a diurnal periodicity, with maximal microfilaremia levels generally observed between 10:00 am and 3:00 pm. {F}ew studies have assessed factors potentially associated with this periodicity. {M}ethods: {M}icrofilaremia data were collected repeatedly between 9:00 am and 8:00 pm from 13 individuals in the {R}epublic of the {C}ongo. {U}sing local polynomial regression ({LOESS}), we determined the best models representing the dynamics of microfilaremia over this period. {I}n a second step, using cosinor models, we evaluated the influence of sex, age, and body temperature on the periodicity of {L}. loa microfilaremia in blood. {R}esults: {A}ll subjects reached their maximum microfilaremia between 10:00 am and 4:00 pm. {I}ndividual microfilaremia showed different patterns between individuals, and some clearly showed multiple peaks within a day. {LOESS} provided a good fit to the observed data. {W}ithout adjustment, the maximum microfilarial density was reached around 11:00 am. {A}djustment revealed three distinct modes of microfilaremia, occurring around 10:00 am, 1:00 pm, and 4:00 pm. {C}osinor models also provided good fit to our data. {A}fter adjustment on body temperature, the {L}. loa microfilaremia fluctuation amplitude decreased significantly from 1684.8 to 310.6 microfilariae(mf)/ml and the predicted peak was estimated at 12:02 pm. {C}onclusions: {W}e characterized the periodicity of {L}. loa microfilaremia mathematically with two different approaches: cosinor models and {LOESS} regression. {B}oth models suggest that body temperature plays a role in the variation in microfilaremia within a day. {F}urther studies are needed to identify individual co-factors affecting microfilaremia.},
  keywords = {{L}oa loa ; {M}icrofilaremia ; {P}eriodicity ; {T}emperature ; {R}epublic of the {C}ongo ; {CONGO}},
  booktitle = {},
  journal = {{P}arasites and {V}ectors},
  volume = {15},
  numero = {1},
  pages = {417 [7 ]},
  ISSN = {1756-3305},
  year = {2022},
  DOI = {10.1186/s13071-022-05541-y},
  URL = {https://www.documentation.ird.fr/hor/fdi:010086486},
}