@article{fdi:010086402,
  title = {{P}re-pandemic cross-reactive immunity against {SARS}-{C}o{V}-2 among {C}entral and {W}est {A}frican populations},
  author = {{S}ouris, {M}arc and {T}shilolo, {L}. and {P}arzy, {D}. and {I}ngoba, {L}. {L}. and {N}toumi, {F}. and {K}amgaing, {R}. and {N}dour, {M}. and {M}bongi, {D}. and {P}hoba, {B}. and {T}shilolo, {M}. {A}. and {M}bungu, {R}. and {S}osso, {M}. {S}. and {F}ainguem, {N}. and {D}ieye, {T}. {N}. and {S}ylla, {M}. and {M}orand, {P}ierre and {G}onzalez, {J}. {P}.},
  editor = {},
  language = {{ENG}},
  abstract = {{F}or more than two years after the emergence of {COVID}-19 ({C}oronavirus {D}isease-2019), significant regional differences in morbidity persist. {T}hese differences clearly show lower incidence rates in several regions of the {A}frican and {A}sian continents. {T}he work reported here aimed to test the hypothesis of a pre-pandemic natural immunity acquired by some human populations in central and western {A}frica, which would, therefore, pose the hypothesis of an original antigenic sin with a virus antigenically close to the {S}evere {A}cute {R}espiratory {S}yndrome {C}oronavirus 2 ({SARS}-{C}o{V}-2). {T}o identify such pre-existing immunity, sera samples collected before the emergence of {COVID}-19 were tested to detect the presence of {I}g{G} reacting antibodies against {SARS}-{C}o{V}-2 proteins of major significance. {S}era samples from {F}rench blood donors collected before the pandemic served as a control. {T}he results showed a statistically significant difference of antibodies prevalence between the collected samples in {A}frica and the control samples collected in {F}rance. {G}iven the novelty of our results, our next step consists in highlighting neutralizing antibodies to evaluate their potential for pre-pandemic protective acquired immunity against {SARS}-{C}o{V}-2. {I}n conclusion, our results suggest that, in the investigated {A}frican sub-regions, the tested populations could have been potentially and partially pre-exposed, before the {COVID}-19 pandemic, to the antigens of a yet non-identified {C}oronaviruses.},
  keywords = {{SARS}-{C}o{V}-2 ; {COVID}-19 ; {C}ovi{D}iag ; natural immunity ; original antigenic ; sin ; {A}frica ; {CONGO} ; {CAMEROUN} ; {SENEGAL} ; {REPUBLIQUE} {DEMOCRATIQUE} {DU} {CONGO}},
  booktitle = {},
  journal = {{V}iruses},
  volume = {14},
  numero = {10},
  pages = {2259 [11 ]},
  year = {2022},
  DOI = {10.3390/v14102259},
  URL = {https://www.documentation.ird.fr/hor/fdi:010086402},
}