@article{fdi:010086397,
  title = {{I}solation, synthesis and absolute configuration of the pericharaxins {A} and {B}, epimeric hydroxy-polyene glycerol ethers from the calcarean sponge {P}ericharax heteroraphis},
  author = {de {M}uizon, {C}. {J}. and {M}oriou, {C}. and {P}etek, {S}ylvain and {E}kins, {M}. and {R}ousseau, {M}. and {A}l {M}ourabit, {A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{N}aturally occurring epimeric hydroxy-polyene glycerol ether pericharaxins {A} (1a) and {B} (1b) were isolated from the calcarean sponge {P}ericharax heteroraphis. {T}he structural and stereochemical characterization of both diastereoisomers were established on the basis of spectroscopic data analysis and total synthesis in seven steps. {T}he mixture of pericharaxins {A} (1a) and {B} (1b) was proven to be epimeric by chiral-phase {HPLC} analysis of both synthetic and natural samples. {F}urther separation of the epimers and application of {M}osher's method to the synthetic compounds allowed unequivocal absolute configuration assignment. {W}hile natural products and the synthetic intermediates were shown to be non-cytotoxic on the {HCT}116 cell line, the endochondral differentiation activity using human type {X} collagen transcription activity in {ATDC}5 cells is interesting.},
  keywords = {marine metabolites ; calcareous sponge ; {P}ericharax ; glycerol ether ; pericharaxin ; {PACIFIQUE} ; {WALLIS}},
  booktitle = {},
  journal = {{M}arine {D}rugs},
  volume = {20},
  numero = {10},
  pages = {635 [14 ]},
  year = {2022},
  DOI = {10.3390/md20100635},
  URL = {https://www.documentation.ird.fr/hor/fdi:010086397},
}