%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Nguyen, P. T. L.
%A Tran, H. T. M.
%A Tran, H. A.
%A Pham, T. D.
%A Luong, T. M.
%A Nguyen, T. H.
%A Nguyen, L. T. P.
%A Nguyen, T. T. T.
%A Hoang, H. T. A.
%A Nguyen, C.
%A Tran, D. N.
%A Dang, A. D.
%A Suzuki, M.
%A Le, T. V.
%A Banuls, Anne-Laure
%A Choisy, Marc
%A Van Doorn, R. H.
%A Tran, H. H.
%T Carriage of plasmid-mediated colistin resistance-1-positive Escherichia coli in humans, animals, and environment on farms in Vietnam
%D 2022
%L fdi:010086301
%G ENG
%J American Journal of Tropical Medicine and Hygiene
%@ 0002-9637
%K VIET NAM
%M ISI:000861115300015
%N 1
%P 65-71
%R 10.4269/ajtmh.21-1203
%U https://www.documentation.ird.fr/hor/fdi:010086301
%> https://www.documentation.ird.fr/intranet/publi/2022-11/010086301.pdf
%V 107
%W Horizon (IRD)
%X Plasmid-Mediated Colistin Resistance 1 (mcr-1) was first reported in 2015 and is a great concern to human health. In this study, we investigated the prevalence of mcr-1 and mcr-1-positive Escherichia coli (MCRPEC) and the association in infection status among various reservoirs connected to livestock. The study was conducted in 70 poultry and swine farms in a commune in Ha Nam province, northern Vietnam. Samples were collected from farmers, food animals, domestic animals, and farm environments (flies and wastewater) for polymerase chain reaction (PCR) screening for mcr-1 gene and species identification of PCR positive isolates. Among 379 obtained mcr-1 positives isolates, Escherichia coli was the major identified, varying from 50% (2/4) in dog feces to 100% (31/31) in humans feces isolates. The prevalence of MCRPEC was 14.4% (20/139), 49.7% (96/193), 31.3% (25/80), 36.7% (40/109), 26.9% (18/67), and 3.9% (2/51) in humans, chickens, pigs, flies, wastewater, and dogs, respectively. The study identified association between MCRPEC infection status in humans and flies (OR = 3.4), between flies and chickens (OR = 5.3), and between flies and pigs (OR = 9.0). Farmers' age and farm livestock unit were also associated factors of MCRPEC infection status in humans (OR = 5.1 and 1.05, respectively). These findings bring new knowledge on antibiotic resistance in livestock setting and important suggestions on potential role of flies in the transmission of mcr-1 resistance gene.
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