@article{fdi:010086086,
  title = {{I}nvestigating bracovirus chromosomal integration and inheritance in lepidopteran host and nontarget species},
  author = {{M}uller, {H}. and {H}eisserer, {C}. and {F}ortuna, {T}aiadjana and {M}ougel, {F}. and {H}uguet, {E}. and {K}aiser, {L}. and {G}ilbert, {C}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}racoviruses ({BV}s) are domesticated viruses found in braconid parasitoid wasp genomes. {T}hey are composed of domesticated genes from a nudivrius, coding viral particles in which wasp {DNA} circles are packaged. {BV}s are viewed as possible vectors of horizontal transfer of genetic material ({HT}) from wasp to their hosts because they are injected, together with wasp eggs, by female wasps into their host larvae, and because they undergo massive chromosomal integration in multiple host tissues. {H}ere, we show that chromosomal integrations of the {C}otesia typhae {BV} ({C}t{BV}) persist up to the adult stage in individuals of its natural host, {S}esamia nonagrioides, that survived parasitism. {H}owever, while reproducing host adults can bear an average of nearly two {C}t{BV} integrations per haploid genome, we were unable to retrieve any of these integrations in 500 of their offspring using {I}llumina sequencing. {T}his suggests either that host gametes are less targeted by {C}t{BV}s than somatic cells or that gametes bearing {BV} integrations are nonfunctional. {W}e further show that {C}t{BV} can massively integrate into the chromosomes of other lepidopteran species that are not normally targeted by the wasp in the wild, including one which is divergent by at least 100 million years from the natural host. {C}ell entry and chromosomal integration of {BV}s are thus unlikely to be major factors shaping wasp host range. {T}ogether, our results shed new light on the conditions under which {BV}-mediated wasp-to-host {HT} may occur and provide information that may be helpful to evaluate the potential risks of uncontrolled {HT} associated with the use of parasitoid wasps as biocontrol agents.},
  keywords = {bio-control ; {B}raconidae ; bracoviruses ; evolutionnary genomics ; horizontal transfer ; parasitoid wasps ; {FRANCE}},
  booktitle = {},
  journal = {{M}olecular {E}cology},
  volume = {[{E}arly access]},
  numero = {},
  pages = {[14 ]},
  ISSN = {0962-1083},
  year = {2022},
  DOI = {10.1111/mec.16685},
  URL = {https://www.documentation.ird.fr/hor/fdi:010086086},
}