Uysal I. B. auteur aut IRD Boue V. auteur aut IRD Murall C. L. auteur aut IRD Graf C. auteur aut IRD Selinger Christian auteur aut IRD Hirtz C. auteur aut IRD Bernat C. auteur aut IRD Ravel J. auteur aut IRD Reynes J. auteur aut IRD Bonneau M. auteur aut IRD Rahmoun M. auteur aut IRD Segondy M. auteur aut IRD Boulle N. auteur aut IRD Grasset S. auteur aut IRD Groc S. auteur aut IRD Waterboer T. auteur aut IRD Tribout V. auteur aut IRD Bravo I. G. auteur aut IRD Burrel S. auteur aut IRD Foulongne V. auteur aut IRD Alizon S. auteur aut IRD Tessandier N. auteur aut IRD text journalArticle eng text/pdf reformatted digital access Human papillomaviruses (HPVs), the most oncogenic virus known to humans, are often associated with Herpes Simplex Virus-2 (HSV-2) infections. The involvement of the latter in cervical cancer is controversial but its long-term infections might modulate the mucosal microenvironment in a way that favors carcinogenesis. We know little about coinfections between HSV-2 and HPVs, and studying the immunological and microbiological dy-namics in the early stages of these infections may help identify or rule out potential interactions. We report two cases of concomitant productive, although asymptomatic, HSV-2 and HPV infections in young women (aged 20 and 25). The women were followed up for approximately a year, with clinical visits every two months and weekly self-samples. We performed quantitative analyses of their HSV-2 and HPV viral loads, immunological responses (IgG and IgM antibodies and local cytokines expression profiles), vaginal microbiota composition, as well as demographic and behavior data. We detect interactions between virus loads, immune response, and the vaginal microbiota, which improve our understanding of HSV-2 and HPVs' coinfections and calls for further investigation with larger cohorts. specialized Human papillomavirus Herpes Simplex Virus -2 Co -infection Interaction Vaginal microbiota qPCR 052 050 020 30 e01604 [7 ] 2022 2214-2509 https://www.documentation.ird.fr/hor/fdi:010086084 10.1016/j.idcr.2022.e01604 2214-2509 [F B010086084] https://www.documentation.ird.fr/hor/fdi:010086084 https://horizon.documentation.ird.fr/exl-doc/pleins_textes/2022-10/010086084.pdf IRD - Base Horizon / Pleins textes 2022-10-07 2025-02-24 fdi:010086084 fre