@article{fdi:010086084,
  title = {{C}oncomitant and productive genital infections by {HSV}-2 and {HPV} in two young women : a case report},
  author = {{U}ysal, {I}. {B}. and {B}oue, {V}. and {M}urall, {C}. {L}. and {G}raf, {C}. and {S}elinger, {C}hristian and {H}irtz, {C}. and {B}ernat, {C}. and {R}avel, {J}. and {R}eynes, {J}. and {B}onneau, {M}. and {R}ahmoun, {M}. and {S}egondy, {M}. and {B}oulle, {N}. and {G}rasset, {S}. and {G}roc, {S}. and {W}aterboer, {T}. and {T}ribout, {V}. and {B}ravo, {I}. {G}. and {B}urrel, {S}. and {F}oulongne, {V}. and {A}lizon, {S}. and {T}essandier, {N}.},
  editor = {},
  language = {{ENG}},
  abstract = {{H}uman papillomaviruses ({HPV}s), the most oncogenic virus known to humans, are often associated with {H}erpes {S}implex {V}irus-2 ({HSV}-2) infections. {T}he involvement of the latter in cervical cancer is controversial but its long-term infections might modulate the mucosal microenvironment in a way that favors carcinogenesis. {W}e know little about coinfections between {HSV}-2 and {HPV}s, and studying the immunological and microbiological dy-namics in the early stages of these infections may help identify or rule out potential interactions. {W}e report two cases of concomitant productive, although asymptomatic, {HSV}-2 and {HPV} infections in young women (aged 20 and 25). {T}he women were followed up for approximately a year, with clinical visits every two months and weekly self-samples. {W}e performed quantitative analyses of their {HSV}-2 and {HPV} viral loads, immunological responses ({I}g{G} and {I}g{M} antibodies and local cytokines expression profiles), vaginal microbiota composition, as well as demographic and behavior data. {W}e detect interactions between virus loads, immune response, and the vaginal microbiota, which improve our understanding of {HSV}-2 and {HPV}s' coinfections and calls for further investigation with larger cohorts.},
  keywords = {{H}uman papillomavirus ; {H}erpes {S}implex {V}irus -2 ; {C}o -infection ; {I}nteraction ; {V}aginal microbiota ; q{PCR}},
  booktitle = {},
  journal = {{I}dcases},
  volume = {30},
  numero = {},
  pages = {e01604 [7 ]},
  ISSN = {2214-2509},
  year = {2022},
  DOI = {10.1016/j.idcr.2022.e01604},
  URL = {https://www.documentation.ird.fr/hor/fdi:010086084},
}