@article{fdi:010086080,
  title = {{C}ongenital tremor and splay leg in piglets - insights into the virome, local cytokine response, and histology},
  author = {{S}tenberg, {H}. and {H}ellman, {S}. and {L}indstrom, {L}. and {J}acobson, {M}. and {F}ossum, {C}. and {H}ayer, {J}uliette and {M}almberg, {M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {A}typical porcine pestivirus ({APPV}) is a neurotropic virus associated with congenital tremor type {A}-{II}. {A} few experimental studies also indicate an association between {APPV} and splay leg. {T}he overarching aim of the present study was to provide insights into the virome, local cytokine response, and histology of the {CNS} in piglets with signs of congenital tremor or splay leg. {R}esults: {C}haracterization of the cytokine profile and virome of the brain in piglets with signs of congenital tremor revealed an {APPV}-associated upregulation of {S}timulator of interferon genes ({STING}). {T}he upregulation of {STING} was associated with an increased expression of the gene encoding {IFN}-alpha but no differential expression was recorded for the genes encoding {CXCL}8, {IFN}-beta, {IFN}-gamma, {IL}-1 beta, {IL}-6, or {IL}-10. {N}o viral agents or cytokine upregulation could be detected in the spinal cord of piglets with signs of splay leg or in the brain of piglets without an {APPV}-infection. {T}he histopathological examination showed no lesions in the {CNS} that could be attributed to the {APPV}-infection, as no difference between sick and healthy piglets could be seen. {C}onclusion: {T}he results from this study provide evidence of an {APPV}-induced antiviral cytokine response but found no lesions related to the infection nor any support for a common causative agent.},
  keywords = {{C}ongenital tremor ; {T}ype {A}-{II} ; {A}typical porcine pestivirus ; {S}play legs ; {S}weden ; {P}igs ; {P}iglets ; {P}athology ; {I}mmunology ; {V}irome ; {IFN}-alpha ; {STING} ; {SUEDE}},
  booktitle = {},
  journal = {{BMC} {V}eterinary {R}esearch},
  volume = {18},
  numero = {1},
  pages = {348 [12 p.]},
  year = {2022},
  DOI = {10.1186/s12917-022-03443-w},
  URL = {https://www.documentation.ird.fr/hor/fdi:010086080},
}