@article{fdi:010086006,
  title = {{A}ssociation of {N}-acetyl asparagine with {QT}c in diabetes : a metabolomics study},
  author = {{G}ravina, {G}. and {M}oey, {M}. {Y}. {Y}. and {P}rifti, {E}di and {I}chou, {F}. and {B}ourron, {O}. and {B}alse, {E}. and {B}adillini, {F}. and {F}unck-{B}rentano, {C}. and {S}alem, {J}. {E}.},
  editor = {},
  language = {{ENG}},
  abstract = {{C}hanges in the cardio-metabolomics profile and hormonal status have been associated with long {QT} syndrome, sudden cardiac death and increased mortality. {T}he mechanisms underlying {QT}c duration are not fully understood. {T}herefore, an identification of novel markers that complement the diagnosis in these patients is needed. {I}n the present study, we performed untargeted metabolomics on the sera of diabetic patients at a high risk of cardiovascular disease, followed up for 2.55 [2.34-2.88] years ({NCT}02431234), with the aim of identifying the metabolomic changes associated with {QT}c. {W}e used independent weighted gene correlation network analysis ({WGCNA}) to explore the association between metabolites clusters and {QT}c at {T}1 (baseline) and {T}2 (follow up). {T}he overlap of the highly correlated modules at {T}1 and {T}2 identified {N}-{A}cetyl asparagine as the only metabolite in common, which was involved with the urea cycle and metabolism of arginine, proline, glutamate, aspartate and asparagine. {T}his analysis was confirmed by applying mixed models, further highlighting its association with {QT}c. {I}n the current study, we were able to identify a metabolite associated with {QT}c in diabetic patients at two chronological time points, suggesting a previously unrecognized potential role of {N}-{A}cetyl asparagine in diabetic patients suffering from long {QT}c.},
  keywords = {metabolomics ; diabetes ; {N}-{A}cetyl asparagine ; {QT}c},
  booktitle = {},
  journal = {{B}iomedicines},
  volume = {10},
  numero = {8},
  pages = {1955 [9 p.]},
  year = {2022},
  DOI = {10.3390/biomedicines10081955},
  URL = {https://www.documentation.ird.fr/hor/fdi:010086006},
}