Djidjou-Demasse Ramsès auteur aut IRD Mann-Manyombe M. L. auteur aut IRD Seydi O. auteur aut IRD Yatat-Djeumen V. auteur aut IRD text journalArticle eng text/pdf born digital access Plasmodium species exhibit differential preferences for red blood cells (RBCs) of different ages. From a fundamental standpoint, we propose an age-structured within-host malaria model taking into account the variation in RBCs preference. We show that such a differential ecological characteristic of Plasmodium species within their human host is fundamental to capture species diversity within the same infected host individual. We show that with such difference in the RBCs preferences, the long-term coexistence of different species is possible under a certain condition, basically based on a suitable order on the basic reproduction numbers of each species. In particular, we show that the dynamical behavior of the model is not trivial and can range from the extinction of all species, the persistence of a single species, to the coexistence of more than one species. We also describe how our general analysis can be applied in some coinfection configurations including three malaria species: Plasmodium falciparum, Plasmodium vivax, and/or Plasmodium malariae. This improved understanding of the within-host parasite multiplication in a context of mixed Plasmodium species interactions. specialized malaria mathematical modeling nonlinear dynamical system RBC preference within-host coexistence 052 020 [Early access] [30 ] 2022 0022-2526 https://www.documentation.ird.fr/hor/fdi:010085935 10.1111/sapm.12527 0022-2526 [F B010085935] https://www.documentation.ird.fr/hor/fdi:010085935 https://www.documentation.ird.fr/intranet/publi/2022-09/010085935.pdf Accès réservé (Intranet de l'IRD) IRD - Base Horizon / Pleins textes 2022-09-28 2025-02-24 fdi:010085935 fre