@article{fdi:010085934,
  title = {{U}sing an antimalarial in mosquitoes overcomes {A}nopheles and {P}lasmodium resistance to malaria control strategies},
  author = {{P}aton, {D}. {G}. and {P}robst, {A}. {S}. and {M}a, {E}. {R}. {C}. and {A}dams, {K}. {L}. and {S}haw, {W}. {R}. and {S}ingh, {N}. and {B}opp, {S}. and {V}olkman, {S}. {K}. and {H}ien, {D}. {F}. {S}. and {P}are, {P}. {S}. {L}. and {Y}erbanga, {R}. {S}. and {D}iabate, {A}. and {D}abire, {R}. {K}. and {L}ef{\`e}vre, {T}hierry and {W}irth, {D}. {F}. and {C}atteruccia, {F}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he spread of insecticide resistance in {A}nopheles mosquitoes and drug resistance in {P}lasmodium parasites is contributing to a global resurgence of malaria, making the generation of control tools that can overcome these roadblocks an urgent public health priority. {W}e recently showed that the transmission of {P}lasmodium falciparum parasites can be efficiently blocked when exposing {A}nopheles gambiae females to antimalarials deposited on a treated surface, with no negative consequences on major components of mosquito fitness. {H}ere, we demonstrate this approach can overcome the hurdles of insecticide resistance in mosquitoes and drug resistant in parasites. {W}e show that the transmission-blocking efficacy of mosquito-targeted antimalarials is maintained when field-derived, insecticide resistant {A}nopheles are exposed to the potent cytochrome b inhibitor atovaquone, demonstrating that this drug escapes insecticide resistance mechanisms that could potentially interfere with its function. {M}oreover, this approach prevents transmission of field-derived, artemisinin resistant {P}. falciparum parasites ({K}elch13 {C}580{Y} mutant), proving that this strategy could be used to prevent the spread of parasite mutations that induce resistance to front-line antimalarials. {A}tovaquone is also highly effective at limiting parasite development when ingested by mosquitoes in sugar solutions, including in ongoing infections. {T}hese data support the use of mosquito-targeted antimalarials as a promising tool to complement and extend the efficacy of current malaria control interventions. {A}uthor summary{E}ffective control of malaria is hampered by resistance to vector-targeted insecticides and parasite-targeted drugs. {T}his situation is exacerbated by a critical lack of chemical diversity in both interventions and, as such, new interventions are urgently needed. {R}ecent laboratory studies have shown that an alternative approach based on treating {A}nopheles mosquitoes directly with antimalarial compounds can make mosquitoes incapable of transmitting the {P}lasmodium parasites that cause malaria. {W}hile promising, showing that mosquito-targeted antimalarials remain effective against wild parasites and mosquitoes, including drug- and insecticide-resistant populations in malaria-endemic countries, is crucial to the future viability of this approach. {I}n this study, carried out in the {US} and {B}urkina {F}aso, we show that insecticide-resistance mechanisms found in highly resistant, natural {A}nopheles mosquito populations do not interfere with the transmission blocking activity of tarsal exposure to the antimalarial atovaquone, and that mosquito-targeted antimalarial exposure can block transmission of parasites resistant to the main therapeutic antimalarial drug artemisinin. {B}y combining lab, and field-based studies in this way we have demonstrated that this novel approach can be effective in areas where conventional control measures are no longer as effective.},
  keywords = {{BURKINA} {FASO}},
  booktitle = {},
  journal = {{PL}o{S} {P}athogens},
  volume = {18},
  numero = {6},
  pages = {e1010609 [21 p.]},
  ISSN = {1553-7366},
  year = {2022},
  DOI = {10.1371/journal.ppat.1010609},
  URL = {https://www.documentation.ird.fr/hor/fdi:010085934},
}