@article{fdi:010085884,
  title = {{G}enetic diversity of the {LILRB}1 and {LILRB}2 coding regions in an admixed {B}razilian population sample},
  author = {de {O}liveira, {M}. {L}. {G}. and {C}astelli, {E}. {C}. and {V}eiga-{C}astelli, {L}. {C}. and {P}ereira, {A}. {E}. and {M}arcorin, {L}. and {C}arratto, {T}. {M}. {T}. and {S}ouza, {A}. {S}. and {A}ndrade, {H}. {S}. and {S}imoes, {A}. {L}. and {D}onadi, {E}. {A}. and {C}ourtin, {D}avid and {S}abbagh, {A}. and {G}iuliatti, {S}. and {M}endes-{J}unior, {C}. {T}.},
  editor = {},
  language = {{ENG}},
  abstract = {{L}eukocyte immunoglobulin ({I}g)-like receptors ({LILR}) {LILRB}1 and {LILRB}2 may play a pivotal role in maintaining self-tolerance and modulating the immune response through interaction with classical and nonclassical {HLA} molecules. {A}lthough both diversity and natural selection patterns over {HLA} genes have been extensively evaluated, little information is available concerning the genetic diversity and selection signatures on the {LILRB}1/2 regions. {T}herefore, we identified the {LILRB}1/2 genetic diversity using next-generation sequencing in a population sample from {S}ao {P}aulo {S}tate, {B}razil. {W}e identified 58 {LILRB}1 {S}ingle {N}ucleotide {V}ariants ({SNV}s), which gave rise to 13 haplotypes, and 41 {LILRB}2 {SNV}s arranged into 11 haplotypes. {A}lthough we may not exclude as a possible effect of population structure, we found evidence of either positive or purifying selection on {LILRB}1/2 coding regions. {S}ome residues in both proteins showed to be under the effect of positive selection, suggesting that amino acid replacements in these proteins resulted in beneficial functional changes. {F}inally, we have revealed that allelic variation (six and five amino acid exchanges in {LILRB}1 and {LILRB}2, respectively) affects the structure and/or stability of both molecules. {N}onetheless, {LILRB}2 has shown higher average stability, with no {D}1/{D}2 residue affecting protein structure. {O}verall, our findings demonstrate that {LILRB}1 and {LILRB}2 are as polymorphic as {HLA} class {I}b genes and provide strong evidence supporting the directional selection regime hypothesis.},
  keywords = {evolution ; immunity genes ; {LILRB}1 ; {LILRB}2 ; natural selection ; protein ; stability ; {BRESIL} ; {SAO} {PAULO} {ETAT}},
  booktitle = {},
  journal = {{HLA}},
  volume = {[{E}arly access]},
  numero = {},
  pages = {[24 p.]},
  ISSN = {2059-2302},
  year = {2022},
  DOI = {10.1111/tan.14725},
  URL = {https://www.documentation.ird.fr/hor/fdi:010085884},
}