@article{fdi:010085882,
  title = {{P}lacental malaria is associated with higher {LILRB}2 expression in monocyte subsets and lower anti-malarial {I}g{G} antibodies during infancy},
  author = {{D}echavanne, {C}{\'e}lia and {N}ouatin, {O}. and {A}damou, {R}. and {E}dslev, {S}. and {H}ansen, {A}. and {M}eurisse, {F}. and {S}adissou, {I}. and {G}baguidi, {E}. and {M}ilet, {J}acqueline and {C}ottrell, {G}illes and {G}ineau, {L}. and {S}abbagh, {A}. and {M}assougbodji, {A}. and {M}outairou, {K}. and {D}onadi, {E}. {A}. and {C}arosella, {E}. {D}. and {M}oreau, {P}. and {R}emarque, {E}. and {T}heisen, {M}. and {R}ouas-{F}reiss, {N}. and {G}arcia, {A}ndr{\'e} and {F}avier, {B}. and {C}ourtin, {D}avid},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground{P}lacental malaria ({PM}) is associated with a higher susceptibility of infants to {P}lasmodium falciparum ({P}f) malaria. {A} hypothesis of immune tolerance has been suggested but no clear explanation has been provided so far. {O}ur goal was to investigate the involvement of inhibitory receptors {LILRB}1 and {LILRB}2, known to drive immune evasion upon ligation with pathogen and/or host ligands, in {PM}-induced immune tolerance. {M}ethod{I}nfants of women with or without {PM} were enrolled in {A}llada, southern {B}enin, and followed-up for 24 months. {A}ntibodies with specificity for five blood stage parasite antigens were quantified by {ELISA}, and the frequency of immune cell subsets was quantified by flow cytometry. {LILRB}1 or {LILRB}2 expression was assessed on cells collected at 18 and 24 months of age. {F}indings{I}nfants born to women with {PM} had a higher risk of developing symptomatic malaria than those born to women without {PM} ({IRR}=1.53, p=0.040), and such infants displayed a lower frequency of non-classical monocytes ({OR}=0.74, p=0.01) that overexpressed {LILRB}2 ({OR}=1.36, p=0.002). {M}oreover, infants born to women with {PM} had lower levels of cytophilic {I}g{G} and higher levels of {IL}-10 during active infection. {I}nterpretation{M}odulation of {I}g{G} and {IL}-10 levels could impair monocyte functions (opsonisation/phagocytosis) in infants born to women with {PM}, possibly contributing to their higher susceptibility to malaria. {T}he long-lasting effect of {PM} on infants' monocytes was notable, raising questions about the capacity of ligands such as {R}ifins or {HLA}-{I} molecules to bind to {LILRB}1 and {LILRB}2 and to modulate immune responses, and about the reprogramming of neonatal monocytes/macrophages.},
  keywords = {{LILRB}1 ; {LILRB}2 ; {P}lasmodium falciparum ; immune tolerance ; {HLA}-{G} ; {G}d {T} ; cell ; monocytes ; malaria candidate vaccine ; {BENIN}},
  booktitle = {},
  journal = {{F}rontiers in {I}mmunology},
  volume = {13},
  numero = {},
  pages = {909831 [12 ]},
  ISSN = {1664-3224},
  year = {2022},
  DOI = {10.3389/fimmu.2022.909831},
  URL = {https://www.documentation.ird.fr/hor/fdi:010085882},
}