Publications des scientifiques de l'IRD

Touret F., Baronti Cécile, Pastorino B., Villarroel P. M. S., Ninove L., Nougairede A., Lamballerie de X. (2022). In vitro activity of therapeutic antibodies against SARS-CoV-2 Omicron BA.1, BA.2 and BA.5. Scientific Reports - Nature, 12 (1), p. 12609 [6 p.]. ISSN 2045-2322.

Titre du document
In vitro activity of therapeutic antibodies against SARS-CoV-2 Omicron BA.1, BA.2 and BA.5
Année de publication
2022
Type de document
Article référencé dans le Web of Science WOS:000830058200001
Auteurs
Touret F., Baronti Cécile, Pastorino B., Villarroel P. M. S., Ninove L., Nougairede A., Lamballerie de X.
Source
Scientific Reports - Nature, 2022, 12 (1), p. 12609 [6 p.] ISSN 2045-2322
The replacement of the Omicron BA.1 variant of SARS-CoV-2 by the BA.2 and the rapid growth of the BA.5 sub lineage, which have both different sets of mutations in the spike glycoprotein, alters the spectrum of activity of therapeutic antibodies currently licensed in the European Union. Using clinical strains of the Omicron BA.2 and BA.5 variants, we compared the neutralising power of monoclonal antibodies against the Omicron BA.1, BA.2 and BA.5 variants, using an ancestral strain (lineage B.1, D614G) and a Delta variant strain as reference. Sotrovimab/Vir-7831 is less active against BA.2 than against BA.1 (fold change reduction similar to 1,4) and even less active against BA.5 (fold change reduction similar to 2.7). Within the Evusheld /AZD7442 cocktail, Cilgavimab/AZD1061 is more active against BA.2 and BA.5 than against BA.1 (fold change increase similar to 32), whilst the very low activity of Tixagevimab/AZD8895 against BA.1 is not enhanced against BA.2 nor BA.5. In total, compared to BA.1, the activity of the Evusheld/AZD7442 is significantly improved against BA.2 while BA.5 is intermediate but closer to BA.2.
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020] ; Entomologie médicale / Parasitologie / Virologie [052]
Localisation
Fonds IRD [F B010085876]
Identifiant IRD
fdi:010085876
Contact